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If you’re dealing with mild to moderate pain, inflammation, or fever, your doctor or pharmacist might recommend a medication like FENAMIN 250. This article breaks down everything you need to know about this medicine—from what it does, how to take it, to its potential side effects—so you can make informed decisions about your health.
What FENAMIN 250 Is and What It Is Used For
FENAMIN 250 is a non-steroidal anti-inflammatory drug (NSAID) that contains mefenamic acid as its active ingredient. It is commonly used to relieve:
- Mild to moderate pain
- Inflammation (swelling and redness)
- Fever
It works by reducing the substances in the body that cause inflammation and pain. Because it also has antipyretic properties, it’s effective in reducing fever.
Key Benefits:
| Benefit | Description |
|---|---|
| Pain relief | Effective for headaches, dental pain, and menstrual pain |
| Anti-inflammatory | Helps reduce swelling from injury or chronic conditions |
| Fever reduction | Lowers elevated body temperature |
What You Need to Know Before You Take FENAMIN 250
Do Not Take FENAMIN 250 If:
- You are allergic to mefenamic acid, aspirin, or other NSAIDs.
- You’ve previously experienced symptoms like bronchospasm, rash, or urticaria after using NSAIDs.
- You have or had stomach ulcers, intestinal bleeding, or a perforation caused by NSAID use.
- You suffer from inflammatory bowel diseases such as ulcerative colitis or Crohn’s disease.
- You have epilepsy, liver, kidney, or heart problems.
- You’re recovering from coronary artery bypass graft (CABG) surgery.
- You are pregnant, especially after 20 weeks, or are breastfeeding.
Using NSAIDs after 20 weeks of pregnancy may cause serious complications, including harm to your unborn baby. Always consult your healthcare provider.
Warnings and Precautions
Before taking FENAMIN 250, inform your healthcare provider if:
- You have asthma, liver, kidney, or bowel disorders.
- You’ve had a stroke or have heart-related risk factors like high cholesterol, diabetes, or smoking.
- You’re elderly—since side effects like gastrointestinal bleeding are more likely.
- You have a bleeding disorder or are dehydrated.
- You’re experiencing fluid retention, as this medication may exacerbate the issue.
Note: Long-term or inappropriate use may increase your risk of heart attack or stroke.
Children
There is no sufficient information regarding the use of FENAMIN 250 in children. Always consult a pediatrician before administering any NSAID to a child.
Other Medicines and FENAMIN 250
Always tell your doctor or pharmacist about any other medications you are taking, including over-the-counter, herbal, or complementary medicines. Some medicines may interact negatively with FENAMIN 250.
Drugs That May Interact with FENAMIN 250:
| Medication Type | Examples | Potential Issue |
|---|---|---|
| Anticoagulants (blood thinners) | Warfarin, aspirin | Increased bleeding risk |
| Antiplatelets and SSRIs | Fluoxetine, sertraline | Increased risk of bleeding |
| Lithium | — | Increased lithium levels; monitor closely |
| Other NSAIDs | Ibuprofen, diclofenac | Higher risk of ulcers and gastrointestinal issues |
FENAMIN 250 With Food and Drink

Always take FENAMIN 250 with food to reduce the risk of gastrointestinal upset. Avoid alcohol as it may increase the chance of stomach bleeding.
Pregnancy and Breastfeeding
If you’re pregnant, especially after 20 weeks, or planning to conceive, do not take FENAMIN 250 unless explicitly advised by a healthcare professional. Similarly, this medication is not recommended during breastfeeding as it may pass into breast milk.
Driving and Using Machines
FENAMIN 250 may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you.
FENAMIN 250 Contains Lactose Monohydrate
Each capsule contains 55 mg of lactose monohydrate. If you are lactose intolerant or have conditions like galactose intolerance, consult your doctor before use.
How to Take FENAMIN 250
Always follow the instructions provided by your doctor or the leaflet.
Recommended Adult Dosage:
| Condition | Dosage |
|---|---|
| Mild to moderate pain | 500 mg three times a day |
| Acute pain | Initial: 500 mg, then 250 mg every 6 hrs |
- Do not take FENAMIN 250 for longer than 5 days unless directed.
- Swallow the capsules with a glass of water, after food.
If You Take More Than You Should
Overdose may cause serious symptoms like nausea, vomiting, drowsiness, or even kidney problems. If this happens:
- Contact a doctor immediately.
- Alternatively, go to the nearest hospital or poison control center.
If You Forget to Take a Dose
- Take the missed dose as soon as you remember if it’s within a few hours.
- If it’s close to the time for your next dose, skip the missed one.
- Never double up to make up for a missed dose.
Possible Side Effects
Like all medications, FENAMIN 250 may cause side effects. While many people experience none, it’s essential to be aware of the risks.
Stop Taking FENAMIN 250 and Seek Immediate Help If You Experience:
- Swelling of the face, lips, throat
- Severe skin rashes
- Difficulty breathing or swallowing
- Blood in stools or vomiting blood
- Sudden wheezing or hallucinations
- Signs of a heart attack or stroke
These could be signs of a serious allergic or cardiovascular reaction.
Frequent Side Effects:
| Symptom | Description |
|---|---|
| Gastrointestinal issues | Diarrhea, nausea, vomiting |
| Abdominal discomfort | Stomach pain or cramping |
Less Frequent Side Effects:
- Headaches, dizziness
- Constipation or flatulence
- Water retention (swollen ankles)
- Sensory changes like seeing or hearing things
Side Effects with Unknown Frequency:
- Indigestion or heartburn
- Blurred vision
- Skin blistering
If you experience any side effect, no matter how minor, report it to your healthcare provider.
How to Store FENAMIN 250
To ensure this medicine remains effective:
- Store in a cool, dry place (at or below 25°C)
- Protect from light
- Do not store in a bathroom
- Keep in original packaging until ready for use
- Do not use after the expiry date
- Return any unused capsules to a pharmacist
- Do not flush unused medicine down the drain
Important: Keep all medications out of reach of children.
Contents of the Pack and Other Information
What FENAMIN 250 Contains
- Active ingredient: Mefenamic acid 250 mg
- Other ingredients:
- Lactose monohydrate
- Gelatin (E441)
- Titanium dioxide (E171)
- Brilliant blue (E133), Quinoline yellow (E104)
- Croscarmellose sodium, Magnesium stearate
- Povidone K25, Sodium lauryl sulphate
Appearance and Packaging
FENAMIN 250 capsules contain an off-white powder enclosed in a capsule with a turquoise cap and pale-yellow body.
Packaging options:
| Type | Details |
|---|---|
| Bottle | 30 capsules in a white container |
| Blister Pack | 3 strips of 10 capsules, packed in a box |
Holder of Certificate of Registration
Adcock Ingram Limited
1 New Road, Erand Gardens, Midrand, 1685
Private Bag X69, Bryanston, 2021
Final Thoughts
FENAMIN 250 is a trusted over-the-counter medication for managing mild to moderate pain, inflammation, and fever. While effective, it must be used responsibly. Always read the leaflet, follow dosage instructions, and consult your healthcare provider if you have any concerns.
If used correctly, FENAMIN 250 can provide much-needed relief and improve your day-to-day comfort. Stay informed, stay safe—and never hesitate to ask your pharmacist or doctor for guidance.
Sources:SAHPRA






