Generic Names: Mephenesin 150 mg and Paracetamol 500 mg
Brand Name: SPASMEND
Dosage Form: Oral Tablets (sugar-free)
Legal Classification (South Africa): S2 (Pharmacy Only Medicine)
SPASMEND Tablets are a non-prescription (over-the-counter) medication widely used in South Africa to relieve pain associated with muscle tension. With its dual-action formula combining mephenesin and paracetamol, it is an effective treatment option for adults experiencing generalised musculoskeletal pain.
What Is SPASMEND?
SPASMEND is a combination medicine that contains two active ingredients:
- Mephenesin (150 mg): A skeletal muscle relaxant.
- Paracetamol (500 mg): A pain reliever and fever reducer.
These tablets are used to treat pain caused by muscle tightness or tension. It is intended for adult use only and should be taken under the guidance of a pharmacist or healthcare provider.
What Is SPASMEND Used For?
SPASMEND is indicated for the relief of generalised pain related to muscular tension. It is effective in:
- Reducing muscle spasms
- Relieving muscle-related back pain
- Easing stiffness and discomfort from overexertion
- Alleviating pain caused by mild strains or sprains
This medication is ideal for individuals who experience muscle tightness accompanied by discomfort or pain, making day-to-day activities difficult.
How SPASMEND Works
SPASMEND works through the combined action of its ingredients:
Paracetamol:
- Targets the pain centre in the brain
- Reduces pain perception and body temperature (antipyretic effect)
Mephenesin:
- Acts on the central nervous system
- Helps relax skeletal muscles and relieve tension
By addressing both pain and muscle stiffness, SPASMEND offers comprehensive relief.
Ingredients and Composition
| Ingredient | Strength per Tablet |
|---|---|
| Mephenesin | 150 mg |
| Paracetamol | 500 mg |
Other excipients include:
- Microcrystalline cellulose
- Starch maize
- Croscarmellose sodium
- Colloidal silicon dioxide
- Magnesium stearate
- Sodium lauryl sulphate
- Purified talc
- Colourants: D&C Yellow No. 10 aluminium lake, Quinoline Yellow, Indigo carmine lake
Who Should Avoid SPASMEND?
You should NOT use SPASMEND if you:
- Are allergic to mephenesin, paracetamol, or any of the listed excipients
- Have kidney or liver disease
- Are under the age of 18 years
Consult a doctor before using if you have any chronic health conditions.
Warnings and Precautions
Before taking SPASMEND, please take note of the following:
- Avoid alcohol while taking this medication—it may increase drowsiness.
- Do not exceed the recommended dose. Overdose may result in serious liver damage.
- If symptoms persist for more than 10 days, consult a doctor.
- Use caution if you have a history of liver or kidney conditions.
- Not intended for long-term use.
Drug Interactions
SPASMEND may interact with other medications. Inform your doctor or pharmacist if you are taking:
- Barbiturates (e.g., phenobarbital)
- Opioid painkillers
- Other medications containing paracetamol
These combinations can increase the risk of drowsiness, liver toxicity, or serious side effects.
SPASMEND During Pregnancy and Breastfeeding
The safety of SPASMEND during pregnancy and breastfeeding has not been established. You should:
- Avoid using SPASMEND while pregnant or breastfeeding unless prescribed by a healthcare professional
- Always consult your doctor for safer alternatives during pregnancy
Effects on Driving and Operating Machinery
SPASMEND may cause drowsiness or impair your ability to concentrate. Avoid:
- Driving vehicles
- Operating heavy machinery
until you know how the medication affects you.
Directions for Use
Dosage for adults (18 years and older):
- Take 1 or 2 tablets every 4 hours, as needed.
- Do not exceed 8 tablets in 24 hours.
- Take the tablets with water. Food is optional.
- Do not use for more than 10 consecutive days without medical advice.
Missed Dose
If you miss a dose:
- Take it as soon as you remember.
- If it is almost time for your next dose, skip the missed dose.
- Do not double the dose.
Overdose and What to Do
Paracetamol overdose is extremely serious and can lead to liver failure or death.
Signs of overdose:
- Nausea
- Vomiting
- Loss of appetite
- Abdominal pain
- Confusion
If you suspect an overdose:
- Contact a doctor or poison centre immediately
- Seek emergency medical care, even if no symptoms appear
Side Effects of SPASMEND
SPASMEND is generally well-tolerated, but some people may experience side effects.
Common side effects:
| System Affected | Side Effects |
|---|---|
| Central Nervous | Drowsiness, dizziness, fatigue |
| Skin | Rash, itching, hives |
| Gastrointestinal | Nausea, vomiting, abdominal discomfort |
| Blood | Anaemia (rare), low platelet count |
| Cardiovascular | Fast heartbeat, low blood pressure |
Storage Instructions
| Requirement | Details |
|---|---|
| Temperature | Store below 30°C |
| Light and Moisture | Keep in original packaging |
| Child Safety | Keep out of reach of children |
| Expiry | Check expiry date on label |
Do not dispose of medicine in household waste. Return unused or expired medicine to a pharmacy.
Product Description
SPASMEND tablets are:
- Round and flat
- Light green in colour
- Scored for easy splitting
Packaging Information
Available pack sizes:
- 3 x 8 tablets (24 tablets)
- 6 x 8 tablets (48 tablets)
- 5 x 20 tablets (100 tablets)
- HDPE container with silica gel for moisture control
Not all pack sizes may be available in all locations.
Reporting Side Effects
Adverse reactions can be reported to:
- Rxquora Ltd rxquora@gmail.com
Frequently Asked Questions (FAQs)
Can I take SPASMEND for a headache?
Only if the headache is muscle tension-related. It is not suitable for migraines or cluster headaches.
Can I take SPASMEND with alcohol?
Avoid alcohol. It may worsen drowsiness and increase liver risk.
How quickly does SPASMEND work?
Pain relief is usually noticeable within 30 minutes to an hour.
Can I take SPASMEND with other painkillers?
Avoid taking with other paracetamol-containing medications. Ask your pharmacist before combining.
Is SPASMEND habit-forming?
No, it does not contain addictive substances.
Conclusion
SPASMEND is a trusted over-the-counter medication that effectively addresses pain and muscle tension using a well-balanced combination of mephenesin and paracetamol. When taken as directed, it offers fast and reliable relief. However, misuse can lead to serious side effects, especially liver toxicity.
If you experience ongoing pain, worsening symptoms, or any side effects, always consult your healthcare provider. For long-term or complex conditions, SPASMEND should not replace professional medical evaluation.
Manufacturer Information:
Adcock Ingram Limited
1 New Road, Midrand, South Africa
Education:
Sochi Medical College 2014 – 2017
Work experience:
2017 – to date Sochi Pharmacy – Pharmacist
