{"id":2056,"date":"2025-09-25T11:05:03","date_gmt":"2025-09-25T09:05:03","guid":{"rendered":"https:\/\/rxquora.com\/en\/?p=2056"},"modified":"2025-09-25T11:05:08","modified_gmt":"2025-09-25T09:05:08","slug":"durobac-uses-side-effects-warnings-precautions","status":"publish","type":"post","link":"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/","title":{"rendered":"DUROBAC: Uses,Side Effects,Warnings,Precautions"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>It<\/strong> is a prescription-only antibiotic for treating certain bacterial infections. It combines two active ingredients \u2014 <strong>sulfamethoxazole<\/strong> and <strong>trimethoprim<\/strong> \u2014 in tablet form, and is available in standard and double-strength options. Because it only works against particular bacteria, it\u2019s not right for every infection. Your doctor will decide if it suits your condition and advise the correct dose and duration<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_it_is_and_what_it_is_used_for\"><\/span>What it is and what it is used for<span class=\"ez-toc-section-end\"><\/span><\/h2><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/#What_it_is_and_what_it_is_used_for\" >What it is and what it is used for<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/#How_it_works\" >How it works<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/#Who_should_NOT_use_this_medicine\" >Who should NOT use this medicine<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/#Warnings_and_precautions\" >Warnings and precautions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/#Pregnancy_planning_pregnancy_and_breastfeeding\" >Pregnancy, planning pregnancy, and breastfeeding<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/#Interactions\" >Interactions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/#How_to_take_Step-by-step\" >How to take (Step-by-step)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/#Dosing_table_12_years_and_older\" >Dosing table (12 years and older)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/#Possible_side_effects\" >Possible side effects<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/#Serious_%E2%80%94_seek_urgent_medical_help_and_stop_DUROBAC\" >Serious \u2014 seek urgent medical help and stop DUROBAC<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/#Common\" >Common<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/#Less_common\" >Less common<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/#Storage_and_disposal\" >Storage and disposal<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/#What_the_medicine_contains\" >What the medicine contains<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/#Pack_information_and_appearance\" >Pack information and appearance<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/#FAQs\" >FAQs<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Active ingredients and class<\/strong><br>DUROBAC contains <strong>sulfamethoxazole<\/strong> and <strong>trimethoprim<\/strong>, two antibiotics used together to treat infections caused by susceptible bacteria.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Indications (uses) \u2014 as per the source leaflet<\/strong><br>Your doctor may prescribe DUROBAC for bacterial infections such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Lung infections<\/strong> (upper and lower respiratory tract).<\/li>\n\n\n\n<li><strong>Urinary tract infections<\/strong> (including bladder infections).<\/li>\n\n\n\n<li><strong>Gastrointestinal tract infections<\/strong> (mouth, gullet\/oesophagus, stomach, and intestines).<\/li>\n\n\n\n<li><strong>Genital tract infections<\/strong>, including those that are <strong>sexually transmitted<\/strong>.<\/li>\n\n\n\n<li><strong>Skin infections<\/strong>.<\/li>\n\n\n\n<li><strong>Other bacterial infections<\/strong> when the germs are known or expected to be sensitive to this antibiotic combination.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Important:<\/strong> DUROBAC only works against certain bacteria. It won\u2019t help with viruses (like cold or flu) or with infections caused by organisms not sensitive to these antibiotics.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_it_works\"><\/span>How it works <span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Speak to your doctor or pharmacist if you would like more information about how this antibiotic combination works.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Who_should_NOT_use_this_medicine\"><\/span>Who should NOT use this medicine<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Do <strong>not<\/strong> take DUROBAC if any of the following apply to you:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>You are <strong>allergic<\/strong> to <strong>sulfamethoxazole<\/strong>, <strong>trimethoprim<\/strong>, <strong>sulfonamides<\/strong>, or any ingredient listed in this leaflet (see \u201cWhat the medicine contains\u201d).<\/li>\n\n\n\n<li>You have <strong>porphyria<\/strong> (a metabolic\/haem disorder).<\/li>\n\n\n\n<li>You have <strong>severe liver<\/strong> or <strong>severe kidney<\/strong> problems.<\/li>\n\n\n\n<li>You have <strong>anaemia due to folic acid deficiency<\/strong>.<\/li>\n\n\n\n<li>You are <strong>pregnant<\/strong> or <strong>breastfeeding<\/strong>.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Warnings_and_precautions\"><\/span>Warnings and precautions <span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Before taking DUROBAC, tell your doctor if any of these apply to you or occur during treatment:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Weakened immune system:<\/strong> If you have <strong>AIDS<\/strong> or receive <strong>treatments that lower immunity<\/strong> (e.g., after an organ transplant), you may be more likely to experience side effects; your doctor may monitor you more closely.<\/li>\n\n\n\n<li><strong>Serious skin reactions:<\/strong> Stop the tablets and get urgent medical advice if you develop a <strong>rash<\/strong> (especially with flu-like symptoms), <strong>blistering<\/strong>, or <strong>peeling<\/strong> skin. Severe reactions have been reported.<\/li>\n\n\n\n<li><strong>Low folic acid:<\/strong> If you have or are at risk of <strong>folate deficiency<\/strong> (pale skin, tiredness, shortness of breath), your doctor may prescribe <strong>folic acid<\/strong> alongside DUROBAC.<\/li>\n\n\n\n<li><strong>Older adults:<\/strong> You may be more prone to blood problems such as <strong>easy bruising or bleeding<\/strong> (thrombocytopenia), especially if you also use certain <strong>diuretics<\/strong> (e.g., thiazides).<\/li>\n\n\n\n<li><strong>Kidney problems:<\/strong> Your doctor may need to <strong>adjust your dose<\/strong> according to tests. <strong>Drink sufficient fluids<\/strong>, particularly at <strong>higher doses<\/strong>.<\/li>\n\n\n\n<li><strong>Allergy cross-reactivity:<\/strong> If you are allergic to <strong>sulfonamide-containing medicines<\/strong> (e.g., certain diabetes tablets such as gliclazide or glibenclamide, <strong>acetazolamide<\/strong>, or <strong>thiazide diuretics<\/strong>), you may also react to DUROBAC.<\/li>\n\n\n\n<li><strong>Driving and machinery:<\/strong> It isn\u2019t possible to predict how DUROBAC will affect each person. <strong>Do not drive or use machines<\/strong> until you know how it affects you.<\/li>\n\n\n\n<li><strong>Preservative sensitivity:<\/strong> DUROBAC contains <strong>Nipastat<\/strong> (parabens), which <strong>may cause allergic reactions<\/strong>, possibly delayed.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Note:<\/strong> Always tell your doctor or pharmacist about <strong>all<\/strong> medicines and supplements you use, including complementary or traditional products (see \u201cInteractions\u201d).<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pregnancy_planning_pregnancy_and_breastfeeding\"><\/span>Pregnancy, planning pregnancy, and breastfeeding<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Pregnancy:<\/strong> Safety has <strong>not been established<\/strong>. The source states you <strong>should not take DUROBAC while pregnant<\/strong>.<\/li>\n\n\n\n<li><strong>Breastfeeding:<\/strong> Safety has <strong>not been established<\/strong>. The source states you <strong>should not take DUROBAC while breastfeeding<\/strong>.<\/li>\n\n\n\n<li><strong>Planning a pregnancy \/ unsure:<\/strong> <strong>Do not use<\/strong> DUROBAC. <strong>Speak to your doctor or pharmacist before use.<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Interactions\"><\/span>Interactions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Tell your <a href=\"https:\/\/rxquora.com\/en\/adco-contrometuses-dosage-side-effects-and-safety-tips\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/adco-contrometuses-dosage-side-effects-and-safety-tips\/\">healthcare professional<\/a> about every medicine or supplement you take. DUROBAC may interact with the following (as listed in the source):<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Medicines whose effects may increase (monitoring or dose changes may be needed):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Warfarin<\/strong> or other blood thinners.<\/li>\n\n\n\n<li><strong>Methotrexate<\/strong> (used for cancer or immune disorders).<\/li>\n\n\n\n<li><strong>Phenytoin<\/strong> (for epilepsy).<\/li>\n\n\n\n<li><strong>Sulfonylureas<\/strong> for diabetes (<strong>gliclazide<\/strong>, <strong>glibenclamide<\/strong>, <strong>tolbutamide<\/strong>) and <strong>repaglinide<\/strong>.<\/li>\n\n\n\n<li><strong>Digoxin<\/strong> or <strong>procainamide<\/strong> (for heart rhythm problems).<\/li>\n\n\n\n<li><strong>Lamivudine<\/strong> (for HIV) \u2014 high doses of DUROBAC may increase lamivudine\u2019s effects.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Other notable interactions and cautions:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Para-aminobenzoic acid (PABA) supplements:<\/strong> May raise the risk of side effects such as <strong>crystals in the urine<\/strong>.<\/li>\n\n\n\n<li><strong>Cyclosporin<\/strong> (e.g., post-transplant): May <strong>reduce kidney function<\/strong> further.<\/li>\n\n\n\n<li><strong>Pyrimethamine<\/strong> (for malaria or diarrhoea): May increase the risk of <strong>anaemia<\/strong>.<\/li>\n\n\n\n<li><strong>Zidovudine<\/strong> (for HIV): May increase the risk of <strong>low blood cells<\/strong>.<\/li>\n\n\n\n<li><strong>Medicines that raise potassium<\/strong>: e.g., <strong>spironolactone<\/strong> (a diuretic), <strong>steroids<\/strong> (like <strong>prednisolone<\/strong>), <strong>ACE inhibitors<\/strong> (for blood pressure\/heart), and <strong>digoxin<\/strong>. These can push <strong>potassium to dangerous levels<\/strong> when combined.<\/li>\n\n\n\n<li><strong>Folinic acid<\/strong> supplements: May <strong>reduce the effect<\/strong> of DUROBAC.<\/li>\n\n\n\n<li><strong>Hormonal contraceptives:<\/strong> DUROBAC can make <strong>contraceptives less effective<\/strong>. <strong>Use additional protection<\/strong> while on treatment.<\/li>\n\n\n\n<li><strong>Azathioprine<\/strong> (immune conditions \/ after transplant): Your doctor may need to <strong>monitor your blood counts<\/strong> more often.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Food, drink, and alcohol<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Take <strong>with food<\/strong> and a <strong>full glass of water<\/strong>.<\/li>\n\n\n\n<li><strong>Drink plenty of fluids<\/strong> while using DUROBAC.<\/li>\n\n\n\n<li>No specific alcohol advice is provided in the source.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_to_take_Step-by-step\"><\/span>How to take (Step-by-step)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>General guidance<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Always take DUROBAC <strong>exactly as your doctor prescribes<\/strong>.<\/li>\n\n\n\n<li><strong>Swallow tablets after meals<\/strong> with a <strong>glass of water<\/strong>.<\/li>\n\n\n\n<li><strong>Keep well hydrated<\/strong> (drink sufficient water) during treatment.<\/li>\n\n\n\n<li><strong>Finish the full course<\/strong>, even if you feel better earlier, unless your doctor tells you to stop.<\/li>\n\n\n\n<li>If you feel the effect is <strong>too strong or too weak<\/strong>, contact your doctor or pharmacist.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Adult and adolescent dosing (12 years and older)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>DUROBAC (80 mg trimethoprim + 400 mg sulfamethoxazole):<\/strong>\n<ul class=\"wp-block-list\">\n<li>Usual dose: <strong>2 tablets every 12 hours after meals<\/strong>.<\/li>\n\n\n\n<li><strong>Maximum dose:<\/strong> <strong>3 tablets every 12 hours<\/strong> (for particularly severe infections).<\/li>\n\n\n\n<li><strong>Minimum dose for long-term treatment:<\/strong> <strong>1 tablet every 12 hours<\/strong>.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>DUROBAC D\/S (160 mg trimethoprim + 800 mg sulfamethoxazole):<\/strong>\n<ul class=\"wp-block-list\">\n<li>Usual dose: <strong>1 tablet every 12 hours after meals<\/strong>.<\/li>\n\n\n\n<li><strong>Maximum dose:<\/strong> <strong>1\u00bd tablets every 12 hours<\/strong> (for particularly severe infections).<\/li>\n\n\n\n<li><strong>Minimum dose for long-term treatment (&gt;14 days):<\/strong> <strong>\u00bd tablet every 12 hours<\/strong>.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Children<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The source does not provide dosing information for children under 12 years for these tablet strengths. Your doctor will advise if needed.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Kidney (renal) impairment<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Your doctor may <strong>order blood tests<\/strong> and <strong>calculate an adjusted dose<\/strong> based on the results.<\/li>\n\n\n\n<li><strong>No information is provided<\/strong> in the source for dosing in <strong>children with renal failure<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Missed dose<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Take the next dose at the usual time. <strong>Do not double up<\/strong> to make up for the missed tablet.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Overdose<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Taking too much DUROBAC may cause <strong>nausea<\/strong>, <strong>vomiting<\/strong>, <strong>dizziness<\/strong>, or <strong>confusion<\/strong>.<\/li>\n\n\n\n<li><strong>Seek medical attention immediately<\/strong>: contact your doctor, pharmacist, the nearest hospital, or a poison control centre.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Practical tips from the source<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Take doses <strong>regularly every 12 hours<\/strong> to keep levels steady.<\/li>\n\n\n\n<li><strong>Hydration matters:<\/strong> drink plenty of water, especially at <strong>higher doses<\/strong>.<\/li>\n\n\n\n<li><strong>With food:<\/strong> helps with swallowing and may reduce stomach upset.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dosing_table_12_years_and_older\"><\/span>Dosing table (12 years and older)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Formulation<\/th><th>Who<\/th><th>Usual dose (every 12 hours, after meals)<\/th><th>Maximum dose (every 12 hours)<\/th><th>Minimum dose for long-term treatment<\/th><\/tr><\/thead><tbody><tr><td><strong>DUROBAC<\/strong> (80 mg TMP + 400 mg SMX per tablet)<\/td><td>Adults &amp; \u226512 years<\/td><td><strong>2 tablets<\/strong><\/td><td><strong>3 tablets<\/strong> (for severe infections)<\/td><td><strong>1 tablet<\/strong><\/td><\/tr><tr><td><strong>DUROBAC D\/S<\/strong> (160 mg TMP + 800 mg SMX per tablet)<\/td><td>Adults &amp; \u226512 years<\/td><td><strong>1 tablet<\/strong><\/td><td><strong>1\u00bd tablets<\/strong> (for severe infections)<\/td><td><strong>\u00bd tablet<\/strong> (for &gt;14 days)<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Note:<\/strong> TMP = trimethoprim; SMX = sulfamethoxazole.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Possible_side_effects\"><\/span>Possible side effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Like all medicines, DUROBAC can cause <a href=\"https:\/\/rxquora.com\/en\/relislim-uses-side-effects-precautions-and-more\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/relislim-uses-side-effects-precautions-and-more\/\">side effects<\/a>, though not everyone gets them. If your health worsens while taking this medicine, contact your healthcare professional.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Serious_%E2%80%94_seek_urgent_medical_help_and_stop_DUROBAC\"><\/span>Serious \u2014 seek urgent medical help and stop DUROBAC<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Allergic reactions:<\/strong> swelling of the <strong>mouth, tongue, face, or throat<\/strong>, <strong>itching<\/strong>.<\/li>\n\n\n\n<li><strong>Severe skin reactions:<\/strong> widespread <strong>blistering<\/strong>, <strong>peeling<\/strong>, or <strong>painful rash<\/strong>, sometimes with fever or flu-like symptoms.<\/li>\n\n\n\n<li><strong>Breathing problems:<\/strong> <strong>worsening cough<\/strong> or <strong>shortness of breath<\/strong>.<\/li>\n\n\n\n<li><strong>Liver problems:<\/strong> raised liver enzymes on tests; <strong>jaundice<\/strong> (yellow skin\/eyes), <strong>nausea<\/strong>, <strong>vomiting<\/strong>, <strong>loss of appetite<\/strong>, <strong>fever<\/strong>, <strong>itching<\/strong>, <strong>dark urine<\/strong>, feeling unwell.<\/li>\n\n\n\n<li><strong>Aseptic meningitis:<\/strong> <strong>sudden headache<\/strong> or <strong>stiff neck<\/strong> with <strong>fever<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">These reactions can be serious and may require urgent medical treatment or hospital care.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Common\"><\/span>Common <span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sulfamethoxazole-related<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Thrush\/candidiasis<\/strong> (mouth or vaginal fungal infection).<\/li>\n\n\n\n<li><strong>High potassium<\/strong> (may cause <strong>palpitations<\/strong> or irregular heartbeat).<\/li>\n\n\n\n<li><strong>Headache<\/strong>, <strong>nausea<\/strong>, <strong>diarrhoea<\/strong>, <strong>rash<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Trimethoprim-related<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Headache<\/strong>, <strong>itchy skin<\/strong>, <strong>rash<\/strong>, <strong>fever<\/strong>, <strong>nausea<\/strong>, <strong>vomiting<\/strong>, <strong>sore mouth<\/strong>.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Less_common\"><\/span>Less common <span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Pseudomembranous colitis<\/strong> (severe bowel infection causing watery, sometimes <strong>bloody diarrhoea<\/strong>).<\/li>\n\n\n\n<li><strong>Blood cell changes<\/strong> (may feel <strong>tired<\/strong>, <strong>weak<\/strong>, <strong>pale<\/strong>, or get <strong>frequent infections<\/strong>).<\/li>\n\n\n\n<li><strong>Hypothyroidism<\/strong> (tiredness, weight gain, feeling unusually cold).<\/li>\n\n\n\n<li><strong>Low blood sugar<\/strong>; <strong>low sodium<\/strong>; <strong>metabolic acidosis<\/strong> (acid build-up).<\/li>\n\n\n\n<li><strong>Decreased appetite<\/strong>.<\/li>\n\n\n\n<li><strong>Mood\/neurological effects:<\/strong> <strong>depression<\/strong>, <strong>hallucinations<\/strong>, <strong>psychotic disorder<\/strong> (losing touch with reality), <strong>seizures<\/strong>, <strong>dizziness<\/strong>, <strong>fatigue<\/strong>, <strong>insomnia<\/strong>, <strong>tingling or numbness<\/strong> in hands\/feet, <strong>loss of balance or coordination<\/strong> (ataxia).<\/li>\n\n\n\n<li><strong>Eye\/ear effects:<\/strong> <strong>vision disturbances<\/strong> (e.g., flickering\/flashing lights), <strong>temporary short-sightedness<\/strong>, <strong>eye inflammation<\/strong> with pain\/redness, <strong>ringing in the ears<\/strong>.<\/li>\n\n\n\n<li><strong>Skin\/colour changes:<\/strong> <strong>cyanosis<\/strong> (bluish\/greyish skin, nails, lips, or around the eyes).<\/li>\n\n\n\n<li><strong>Mouth and gut:<\/strong> <strong>vomiting<\/strong>, <strong>swollen\/inflamed tongue<\/strong>, <strong>sore mouth<\/strong>, <strong>pancreatitis<\/strong> (severe upper stomach pain with nausea\/vomiting).<\/li>\n\n\n\n<li><strong>Sun sensitivity:<\/strong> rash or <strong>sunburn-like reaction<\/strong> after sun exposure (even on cloudy days).<\/li>\n\n\n\n<li><strong>Muscle\/joint pains:<\/strong> <strong>myalgia<\/strong> and <strong>arthralgia<\/strong>.<\/li>\n\n\n\n<li><strong>Urinary and kidney problems:<\/strong> difficulty passing urine; passing <strong>more or less<\/strong> urine than usual; <strong>blood or cloudiness<\/strong> in urine; <strong>kidney problems<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>What to do:<\/strong> For any troublesome or persistent <a href=\"https:\/\/rxquora.com\/en\/alcophyllexuses-side-effects-precautions-and-more\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/alcophyllexuses-side-effects-precautions-and-more\/\">side effects<\/a>, notify your doctor or pharmacist. For any of the <strong>serious<\/strong> effects above, <strong>stop DUROBAC and get urgent medical help<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Side-effect reporting:<\/strong> You can report side effects to <strong>SAHPRA<\/strong> using the \u201c6.04 Adverse Drug Reaction reporting form\u201d available on SAHPRA\u2019s website.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Storage_and_disposal\"><\/span>Storage and disposal<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Keep out of the reach of children.<\/strong><\/li>\n\n\n\n<li>Store at <strong>or below 25 \u00b0C<\/strong> in the <strong>original container<\/strong>. <strong>Protect from light and moisture<\/strong>.<\/li>\n\n\n\n<li>Do <strong>not<\/strong> use after the <strong>expiry date<\/strong> on the pack.<\/li>\n\n\n\n<li><strong>Return<\/strong> any unused tablets to your <strong>pharmacist<\/strong>.<\/li>\n\n\n\n<li>Do <strong>not<\/strong> dispose of medicines in <strong>drains<\/strong> or the <strong>sewerage system<\/strong> (e.g., toilets).<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_the_medicine_contains\"><\/span>What the medicine contains<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Active substances:<\/strong> <strong>trimethoprim<\/strong> and <strong>sulfamethoxazole<\/strong>.<\/li>\n\n\n\n<li><strong>Other ingredients (excipients):<\/strong> hydrogenated vegetable oil, magnesium stearate, <strong>Nipastat<\/strong> (preservative; a mixture of parahydroxybenzoate esters), pregelatinised maize starch, purified water, sodium carboxymethyl starch, maize starch.<\/li>\n\n\n\n<li><strong>Sugar content:<\/strong> <strong>Sugar free<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Allergy note:<\/strong> Nipastat (parabens) <strong>may cause allergic reactions<\/strong>, which can be <strong>delayed<\/strong>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pack_information_and_appearance\"><\/span>Pack information and appearance<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>DUROBAC (standard strength):<\/strong> flat, white, <strong>bisected<\/strong> tablets with <strong>bevelled edges<\/strong>.<\/li>\n\n\n\n<li><strong>DUROBAC D\/S (double strength):<\/strong> white, <strong>oblong<\/strong>, <strong>biconvex<\/strong>, <strong>bisected<\/strong> tablets.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Pack sizes (may vary by market; not all sizes are marketed):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>DUROBAC:<\/strong> 28 or 56 tablets in LDPE \u201cziploc\u201d patient-ready packs; 100, 500, or 1000 tablets in HDPE containers.<\/li>\n\n\n\n<li><strong>DUROBAC D\/S:<\/strong> 30 or 100 tablets in white securitainers; 1000 tablets in HDPE containers.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FAQs\"><\/span>FAQs<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1) Can I take DUROBAC if I\u2019m pregnant or breastfeeding?<\/strong><br>No. The source states you <strong>should not<\/strong> take DUROBAC if you are <strong>pregnant<\/strong> or <strong>breastfeeding<\/strong>. Speak to your doctor about alternatives.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2) Does DUROBAC affect the pill or other contraceptives?<\/strong><br>Yes. DUROBAC can make <strong>contraceptives less effective<\/strong>. <strong>Use additional protection<\/strong> for the duration of your treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3) How should I take the tablets?<\/strong><br>Swallow the tablets <strong>after meals<\/strong> with a <strong>glass of water<\/strong>. <strong>Drink plenty of fluids<\/strong> each day. Take doses <strong>every 12 hours<\/strong> as prescribed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4) What if I miss a dose?<\/strong><br>Take your next dose at the usual time. <strong>Do not<\/strong> take a <strong>double dose<\/strong> to make up for the missed tablet.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>5) What should I do in an overdose?<\/strong><br>Symptoms may include <strong>nausea<\/strong>, <strong>vomiting<\/strong>, <strong>dizziness<\/strong>, and <strong>confusion<\/strong>. <strong>Seek medical help immediately<\/strong>: contact your doctor, pharmacist, nearest hospital, or a poison control centre.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>6) I have kidney problems \u2014 can I still use DUROBAC?<\/strong><br>Your doctor may need to <strong>adjust the dose<\/strong> after <strong>blood tests<\/strong>. For <strong>children with renal failure<\/strong>, the source provides <strong>no dosing information<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>7) Is DUROBAC sugar free?<\/strong><br>Yes, DUROBAC is <strong>sugar free<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>8) Does DUROBAC contain preservatives or common allergens?<\/strong><br>Yes. It contains <strong>Nipastat<\/strong> (parabens), which <strong>may cause allergic reactions<\/strong>, sometimes <strong>delayed<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>9) Can DUROBAC make me drowsy or affect driving?<\/strong><br>It\u2019s <strong>not possible to predict<\/strong> individual effects. <strong>Do not drive or use machines<\/strong> until you know how DUROBAC affects you.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>10) Do I need to finish the whole course?<\/strong><br>Yes. It\u2019s <strong>important to complete<\/strong> the full course your doctor prescribed, unless your doctor advises otherwise.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><\/h2>\n","protected":false},"excerpt":{"rendered":"<p>It is a prescription-only antibiotic for treating certain bacterial infections. It combines two active ingredients \u2014 sulfamethoxazole and trimethoprim \u2014 in tablet form, and is available in standard and double-strength options. Because it only works against particular bacteria, it\u2019s not right for every infection. Your doctor will decide if it suits your condition and advise &#8230; <a title=\"DUROBAC: Uses,Side Effects,Warnings,Precautions\" class=\"read-more\" href=\"https:\/\/rxquora.com\/en\/durobac-uses-side-effects-warnings-precautions\/\" aria-label=\"Read more about DUROBAC: Uses,Side Effects,Warnings,Precautions\">Read more<\/a><\/p>\n","protected":false},"author":5,"featured_media":2506,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[172],"tags":[],"class_list":["post-2056","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-infections"],"_links":{"self":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/posts\/2056","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/comments?post=2056"}],"version-history":[{"count":0,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/posts\/2056\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/media\/2506"}],"wp:attachment":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/media?parent=2056"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/categories?post=2056"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/tags?post=2056"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}