{"id":2111,"date":"2025-09-24T18:00:20","date_gmt":"2025-09-24T16:00:20","guid":{"rendered":"https:\/\/rxquora.com\/en\/?p=2111"},"modified":"2025-09-24T18:00:25","modified_gmt":"2025-09-24T16:00:25","slug":"brufen-400-uses-side-effects-warnings-precautions","status":"publish","type":"post","link":"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/","title":{"rendered":"BRUFEN 400 : Uses,Side Effects,Warnings,Precautions"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>It<\/strong> is a film-coated tablet used to relieve mild to moderate pain of inflammatory origin and to reduce fever. It is suitable for short-term use in adults and adolescents from 12 years and older. The medicine belongs to the non-steroidal anti-inflammatory drug (NSAID) group and offers pain-relief, anti-inflammatory and fever-reducing actions.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_it_is_and_what_it_is_used_for\"><\/span>What it is and what it is used for<span class=\"ez-toc-section-end\"><\/span><\/h2><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/#What_it_is_and_what_it_is_used_for\" >What it is and what it is used for<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/#How_it_works\" >How it works<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/#Who_should_NOT_use_this_medicine\" >Who should NOT use this medicine<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/#Warnings_and_precautions_Read_before_use\" >Warnings and precautions (Read before use)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/#Pregnancy_planning_pregnancy_and_breastfeeding\" >Pregnancy, planning pregnancy, and breastfeeding<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/#Interactions\" >Interactions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/#How_to_take_Step-by-step\" >How to take (Step-by-step)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/#Dosing_table\" >Dosing table<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/#Possible_side_effects\" >Possible side effects<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/#Common_frequent\" >Common frequent<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/#Less_common\" >Less common<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/#Serious_%E2%80%94_seek_urgent_help\" >Serious \u2014 seek urgent help<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/#Storage_and_disposal\" >Storage and disposal<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/#What_the_medicine_contains\" >What the medicine contains<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/#Pack_information_and_appearance\" >Pack information and appearance<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/#FAQs\" >FAQs<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Active ingredient and class:<\/strong> Each film-coated tablet contains <strong>ibuprofen 400 mg<\/strong>, an NSAID with anti-inflammatory, pain-relieving and fever-reducing properties.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Indications\/uses :<\/strong> Treatment of <strong>mild to moderate pain of inflammatory origin<\/strong> and <strong>fever<\/strong>, including:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Soft-tissue injuries (sprains and strains)<\/li>\n\n\n\n<li>Headache<\/li>\n\n\n\n<li>Back pain of musculoskeletal origin<\/li>\n\n\n\n<li>Fever<\/li>\n\n\n\n<li>Muscular aches and pains<\/li>\n\n\n\n<li>Menstrual pain<\/li>\n\n\n\n<li>Dental pain<\/li>\n\n\n\n<li>Pain associated with migraine<\/li>\n\n\n\n<li>Earache<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_it_works\"><\/span>How it works <span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Ibuprofen works through <strong>antiprostaglandin properties<\/strong>, which reduces substances in the body (prostaglandins) that contribute to <strong>inflammation, pain and fever<\/strong>. In practical terms, lowering these signals can ease sore, swollen tissues and bring down a raised temperature.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Absorption note:<\/strong> After an oral dose on an empty stomach, <strong>peak levels occur at about 45 minutes<\/strong>. When taken with food, absorption is <strong>slower<\/strong>, and peak levels are lower.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Who_should_NOT_use_this_medicine\"><\/span>Who should NOT use this medicine<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Do not use BRUFEN 400 EXTRA STRENGTH if you:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Have <strong>peptic ulceration<\/strong> or a <strong>history of GI perforation, ulceration, or bleeding<\/strong> linked to previous NSAID use<\/li>\n\n\n\n<li>Have an <strong>active<\/strong> or <strong>recurrent<\/strong> ulcer, haemorrhage, or perforation<\/li>\n\n\n\n<li>Are in the <strong>third <a href=\"https:\/\/rxquora.com\/en\/1st-trimester-of-pregnancy\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/1st-trimester-of-pregnancy\/\">trimester of pregnancy<\/a><\/strong> or <strong>in labour<\/strong><\/li>\n\n\n\n<li>Are <strong>hypersensitive<\/strong> to ibuprofen, aspirin, or any other NSAID (cross-sensitivity can occur)<\/li>\n\n\n\n<li>Have <strong>heart failure<\/strong><\/li>\n\n\n\n<li>Have <strong>renal (kidney) failure<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Not for children under 12 years.<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Warnings_and_precautions_Read_before_use\"><\/span>Warnings and precautions (Read before use)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Cardiovascular and fluid retention:<\/strong> Use caution if you have a history of <strong>hypertension<\/strong> or <strong>heart failure<\/strong>; <strong>oedema<\/strong> and <strong>fluid retention<\/strong> have been reported. BRUFEN 400 EXTRA STRENGTH can precipitate heart failure in compromised patients.<\/li>\n\n\n\n<li><strong>Older adults:<\/strong> The <strong>elderly<\/strong> have a higher rate of adverse reactions, especially <strong>GI perforation, ulceration and bleeding (PUBs)<\/strong>, which may be fatal.<\/li>\n\n\n\n<li><strong>GI risk:<\/strong> The risk of <strong>PUBs<\/strong> increases at <strong>higher doses<\/strong>, in those with a <strong>history of ulcers<\/strong>, and in the <strong>elderly<\/strong>. <strong>Stop<\/strong> treatment if <strong>GI bleeding or ulceration<\/strong> occurs.<\/li>\n\n\n\n<li><strong>Existing GI disease:<\/strong> Use with care in <strong>ulcerative colitis, Crohn\u2019s disease, hiatus hernia, gastro-oesophageal reflux disease,<\/strong> or <strong>angiodysplasia<\/strong>, as these may be exacerbated.<\/li>\n\n\n\n<li><strong>Serious skin reactions:<\/strong> Rare but severe reactions have been reported, including <strong>exfoliative dermatitis<\/strong>, <strong>Stevens\u2013Johnson syndrome (SJS)<\/strong>, and <strong>toxic epidermal necrolysis (TEN)<\/strong>. <strong>Stop<\/strong> at the first sign of <strong>skin rash<\/strong>, <strong>mucosal lesions<\/strong>, or <strong>other hypersensitivity features<\/strong>.<\/li>\n\n\n\n<li><strong>Pregnancy (third trimester):<\/strong> Regular NSAID use may cause <strong>premature closure of the foetal ductus arteriosus<\/strong> and possibly <strong>persistent pulmonary hypertension<\/strong> of the newborn; labour <strong>onset may be delayed<\/strong> and <strong>duration increased<\/strong>.<\/li>\n\n\n\n<li><strong>Sugar intolerance:<\/strong> Contains <strong>lactose monohydrate<\/strong>. Do not use if you have <strong>galactose intolerance<\/strong>, <strong>Lapp lactase deficiency<\/strong>, or <strong>glucose-galactose malabsorption<\/strong>.<\/li>\n\n\n\n<li><strong>Asthma and allergic disease:<\/strong> Use carefully in <strong>asthma<\/strong> or <strong>bronchospasm<\/strong>; hypersensitivity to aspirin\/NSAIDs suggests higher risk.<\/li>\n\n\n\n<li><strong>Bleeding disorders and anticoagulants:<\/strong> Use with care in <strong>bleeding disorders<\/strong> or if taking <strong>warfarin<\/strong> or other <strong>anticoagulants<\/strong>.<\/li>\n\n\n\n<li><strong>Liver and kidney:<\/strong> Use cautiously in <strong>liver<\/strong> or <strong>renal failure<\/strong>. People with <strong>congestive heart failure, cirrhosis, diuretic-induced volume depletion,<\/strong> or <strong>renal insufficiency<\/strong> may rely on prostaglandins to maintain kidney perfusion and are at <strong>greater risk of renal dysfunction<\/strong> on NSAIDs.<\/li>\n\n\n\n<li><strong>Vision changes:<\/strong> <strong>Stop<\/strong> ibuprofen if you develop <strong>blurred or reduced vision<\/strong> or <strong>changes in colour vision<\/strong>.<\/li>\n\n\n\n<li><strong>Collagen disease:<\/strong> Patients with <strong>collagen disease<\/strong> may have an increased risk of <strong>aseptic meningitis<\/strong>.<\/li>\n\n\n\n<li><strong>Driving and machinery:<\/strong> <strong>Dizziness, drowsiness, fatigue,<\/strong> and <strong>visual disturbances<\/strong> may occur. If affected, <strong>do not drive or operate machinery<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Warning:<\/strong> If you notice <strong>black stools, vomiting blood, severe abdominal pain, a widespread rash, blistering skin, sudden breathing difficulty, facial swelling, or a dramatic drop in urine output<\/strong>, <strong>stop taking the medicine<\/strong> and seek medical advice urgently.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pregnancy_planning_pregnancy_and_breastfeeding\"><\/span>Pregnancy, planning pregnancy, and breastfeeding<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Pregnancy:<\/strong> <strong>Do not use<\/strong> in the <strong>third <a href=\"https:\/\/rxquora.com\/en\/1st-trimester-of-pregnancy\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/1st-trimester-of-pregnancy\/\">trimester<\/a><\/strong> or <strong>during labour<\/strong>. Regular NSAID use in late pregnancy may lead to <strong>premature closure of the foetal ductus arteriosus<\/strong> and possibly <strong>persistent pulmonary hypertension<\/strong> of the newborn; <strong>labour may be delayed<\/strong> and <strong>last longer<\/strong>.<\/li>\n\n\n\n<li><strong>Planning pregnancy:<\/strong> Not specified in the source. <strong>Speak to your doctor or pharmacist before use.<\/strong><\/li>\n\n\n\n<li><strong>Breastfeeding:<\/strong> Not specified in the source. <strong>Speak to your doctor or pharmacist before use.<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Interactions\"><\/span>Interactions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Use caution and discuss with a <a href=\"https:\/\/rxquora.com\/en\/spasmend-tablets-uses-safety-instructions\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/spasmend-tablets-uses-safety-instructions\/\">healthcare professional<\/a> if you take any of the following :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Antihypertensives (including ACE inhibitors), beta-blockers, diuretics:<\/strong> Ibuprofen may <strong>reduce their effect<\/strong>; diuretics can <strong>increase nephrotoxicity risk<\/strong>.<\/li>\n\n\n\n<li><strong>Other NSAIDs:<\/strong> Using <strong>two or more NSAIDs<\/strong> together may <strong>increase side effects<\/strong>.<\/li>\n\n\n\n<li><strong>Corticosteroids:<\/strong> <strong>Higher risk of GI perforation, ulceration or bleeding (PUBs)<\/strong>.<\/li>\n\n\n\n<li><strong>Anticoagulants (e.g., warfarin):<\/strong> Effects may be <strong>enhanced<\/strong>.<\/li>\n\n\n\n<li><strong>Antiplatelet medicines<\/strong> and <strong>SSRIs:<\/strong> <strong>Increased risk of GI bleeding<\/strong>.<\/li>\n\n\n\n<li><strong>Digoxin:<\/strong> May <strong>exacerbate cardiac failure<\/strong>, <strong>reduce GFR<\/strong>, and <strong>increase plasma digoxin levels<\/strong>.<\/li>\n\n\n\n<li><strong>Lithium:<\/strong> <strong>Decreased elimination<\/strong> of lithium.<\/li>\n\n\n\n<li><strong>Ciclosporin:<\/strong> <strong>Increased risk of nephrotoxicity<\/strong>.<\/li>\n\n\n\n<li><strong>Mifepristone:<\/strong> A <strong>theoretical<\/strong> decrease in efficacy due to antiprostaglandin action; limited evidence suggests <strong>co-administration on the day of prostaglandin<\/strong> does <strong>not<\/strong> reduce efficacy for medical termination.<\/li>\n\n\n\n<li><strong>Quinolone antibiotics:<\/strong> Animal data suggest NSAIDs <strong>increase risk of convulsions<\/strong>; combined use may <strong>raise seizure risk<\/strong>.<\/li>\n\n\n\n<li><strong>Aminoglycosides:<\/strong> <strong>Decreased excretion<\/strong> may occur.<\/li>\n\n\n\n<li><strong>Herbal extracts:<\/strong> <strong>Ginkgo biloba<\/strong> may <strong>increase bleeding risk<\/strong>.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_to_take_Step-by-step\"><\/span>How to take (Step-by-step)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Check suitability:<\/strong> Ensure you are <strong>12 years or older<\/strong> and none of the <strong>contraindications<\/strong> apply (e.g., active ulcer, heart failure, renal failure, third-trimester pregnancy, labour, or known NSAID hypersensitivity).<\/li>\n\n\n\n<li><strong>Dose and timing:<\/strong> The <strong>recommended adult dose<\/strong> is <strong>1 tablet (400 mg) every 8 hours<\/strong>.<\/li>\n\n\n\n<li><strong>Daily maximum:<\/strong> Do <strong>not exceed 1,200 mg<\/strong> in 24 hours (i.e., <strong>three 400 mg tablets<\/strong>).<\/li>\n\n\n\n<li><strong>Duration:<\/strong> Use the <strong>lowest effective dose for the shortest possible time<\/strong> needed for symptom relief.<\/li>\n\n\n\n<li><strong>Food and absorption:<\/strong> The medicine is <strong>absorbed more slowly after food<\/strong> and reaches <strong>peak levels faster<\/strong> when taken on an <strong>empty stomach<\/strong>.<\/li>\n\n\n\n<li><strong>Missed dose:<\/strong> <strong>Not specified in the source.<\/strong><\/li>\n\n\n\n<li><strong>Overdose:<\/strong> The most likely symptoms include <strong>epigastric (upper tummy) pain<\/strong> and <strong>nausea<\/strong>. There is <strong>no specific antidote<\/strong>; treatment is <strong>supportive<\/strong>. <strong>Seek urgent medical assistance<\/strong> if too many tablets are taken.<\/li>\n<\/ol>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dosing_table\"><\/span>Dosing table<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Age group<\/th><th>Dose per intake<\/th><th>Frequency<\/th><th>Maximum daily dose<\/th><th>Notes<\/th><\/tr><\/thead><tbody><tr><td><strong>Adults and \u2265 12 years<\/strong><\/td><td><strong>400 mg (1 tablet)<\/strong><\/td><td><strong>Every 8 hours<\/strong><\/td><td><strong>1,200 mg<\/strong><\/td><td>Use the <strong>lowest effective dose<\/strong> for the <strong>shortest time<\/strong><\/td><\/tr><tr><td><strong>Children &lt; 12 years<\/strong><\/td><td>\u2013<\/td><td>\u2013<\/td><td>\u2013<\/td><td><strong>Not to be given<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Indications covered by the above dosing: mild to moderate pain of inflammatory origin (including sprains, strains, dental pain, back pain of musculoskeletal origin, pain associated with migraine, muscular aches, earache, menstrual pain) and <strong>fever<\/strong>.<\/em><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Possible_side_effects\"><\/span>Possible side effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Below are effects reported with ibuprofen as listed in the source. <strong>Stop<\/strong> the medicine and <strong>seek medical advice<\/strong> if <a href=\"https:\/\/rxquora.com\/en\/2nd-trimester-of-pregnancy-symptoms-care-and-exams\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/2nd-trimester-of-pregnancy-symptoms-care-and-exams\/\">serious symptoms<\/a> appear.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Common_frequent\"><\/span>Common frequent<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Gastrointestinal (most commonly observed):<\/strong> Nausea, vomiting, diarrhoea, flatulence, constipation, dyspepsia (indigestion), abdominal pain, melaena (black stools), haematemesis (vomiting blood), ulcerative stomatitis, gastritis; peptic ulcers, perforation or GI bleeding <strong>(sometimes fatal)<\/strong>; worsening of colitis or Crohn\u2019s disease<\/li>\n\n\n\n<li><strong>Nervous system (frequent):<\/strong> <strong>Dizziness, nervousness, tinnitus (ringing in the ears), drowsiness, insomnia<\/strong><\/li>\n\n\n\n<li><strong>Psychiatric (frequent):<\/strong> <strong>Depression<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Less_common\"><\/span>Less common<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Gastrointestinal (less frequent):<\/strong> Abdominal discomfort or pain, nausea, vomiting, GI ulcers (sometimes with bleeding)<\/li>\n\n\n\n<li><strong>Renal and urinary (less frequent):<\/strong> <strong>Acute renal failure, cystitis, haematuria (blood in urine), interstitial nephritis, nephrotic syndrome<\/strong><\/li>\n\n\n\n<li><strong>Hepatobiliary (less frequent):<\/strong> <strong>Hepatotoxicity<\/strong>, abnormalities in liver function tests<\/li>\n\n\n\n<li><strong>Blood and lymphatic (less frequent):<\/strong> <strong>Anaemia, thrombocytopenia (low platelets), neutropenia (low neutrophils), eosinophilia, agranulocytosis<\/strong><\/li>\n\n\n\n<li><strong>Immune (less frequent):<\/strong> <strong>Aseptic meningitis, angio-oedema, anaphylaxis<\/strong><\/li>\n\n\n\n<li><strong>Hypersensitivity (less frequent):<\/strong> <strong>Fever, rashes, exacerbation of asthma, bronchospasm<\/strong><\/li>\n\n\n\n<li><strong>Eye disorders:<\/strong> <strong>Visual impairment, changes in colour perception, toxic amblyopia<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Serious_%E2%80%94_seek_urgent_help\"><\/span>Serious \u2014 seek urgent help<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>GI perforation, ulceration or bleeding<\/strong> (can be <strong>fatal<\/strong>)<\/li>\n\n\n\n<li><strong>Severe skin reactions<\/strong> (bullous reactions) including <strong>Stevens\u2013Johnson syndrome<\/strong> and <strong>toxic epidermal necrolysis<\/strong> (frequency <strong>unknown<\/strong>)<\/li>\n\n\n\n<li><strong>Cardiovascular:<\/strong> <strong>Oedema, hypertension, cardiac failure<\/strong> (frequency unknown)<\/li>\n\n\n\n<li><strong>Severe allergic reactions:<\/strong> <strong>Anaphylaxis<\/strong> or <strong>angio-oedema<\/strong><\/li>\n\n\n\n<li><strong>Acute kidney problems:<\/strong> <strong>Acute renal failure<\/strong><\/li>\n\n\n\n<li><strong>Neurological:<\/strong> <strong>Aseptic meningitis<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>What to do:<\/strong> <strong>Stop<\/strong> taking the medicine and <strong>seek medical advice immediately<\/strong> if you develop any serious symptom such as <strong>black stools, vomiting blood, blistering rash, extensive skin peeling, wheeze or sudden breathing difficulty, facial swelling, severe tummy pain, or markedly reduced urine output<\/strong>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Storage_and_disposal\"><\/span>Storage and disposal<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Store at or below 25 \u00b0C<\/strong>.<\/li>\n\n\n\n<li><strong>Keep out of reach of children<\/strong>.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_the_medicine_contains\"><\/span>What the medicine contains<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Active ingredient:<\/strong> <strong>Ibuprofen 400 mg<\/strong> per film-coated tablet<\/li>\n\n\n\n<li><strong>Excipients:<\/strong> Microcrystalline cellulose, croscamellose sodium, <strong>lactose monohydrate<\/strong>, colloidal anhydrous silica, sodium lauryl sulfate, magnesium stearate, hypromellose, titanium dioxide, purified water, industrial methylated spirit, dry colour dispersion (white 06A28611), opaspray white M-1-7111B<\/li>\n\n\n\n<li><strong>Allergen\/sugar note:<\/strong> <strong>Contains lactose monohydrate<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pack_information_and_appearance\"><\/span>Pack information and appearance<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Appearance:<\/strong> <strong>White, pillow-shaped, film-coated<\/strong> tablet<\/li>\n\n\n\n<li><strong>Packs:<\/strong> <strong>Blister strips of 10 tablets per pack<\/strong> (PVC\/Aluminium or PVC\/PVDC\/Aluminium)<\/li>\n\n\n\n<li><strong>Applicant:<\/strong> Abbott Laboratories S.A. (Pty) Limited<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FAQs\"><\/span>FAQs<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1) What conditions can BRUFEN 400 EXTRA STRENGTH treat?<\/strong><br>It relieves <strong>mild to moderate pain of inflammatory origin<\/strong> (e.g., sprains, strains, back pain of musculoskeletal origin, muscular aches, dental pain, menstrual pain, pain associated with migraine, earache) and <strong>fever<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2) How quickly does it work?<\/strong><br>After a dose on an <strong>empty stomach<\/strong>, peak blood levels are reached in about <strong>45 minutes<\/strong>. <strong>Absorption is slower after food<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3) What is the usual adult dose and maximum daily amount?<\/strong><br><strong>400 mg every 8 hours<\/strong>, with a <strong>maximum of 1,200 mg per day<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4) Can children take it?<\/strong><br><strong>No.<\/strong> It is <strong>not to be given to children under 12 years<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>5) Can I use it in late pregnancy or during labour?<\/strong><br><strong>No.<\/strong> Do not use in the <strong>third <a href=\"https:\/\/rxquora.com\/en\/1st-trimester-of-pregnancy\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/1st-trimester-of-pregnancy\/\">trimester<\/a><\/strong> or <strong>during labour<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>6) I have heart failure or kidney failure. Can I take it?<\/strong><br><strong>No.<\/strong> It is <strong>contraindicated<\/strong> in <strong>heart failure<\/strong> and in <strong>renal failure<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>7) Does it affect driving or operating machines?<\/strong><br>It can cause <strong>dizziness, drowsiness, fatigue,<\/strong> and <strong>visual disturbances<\/strong>. If affected, <strong>do not drive or operate machinery<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>8) Can I take it with my blood pressure tablets or water tablets (diuretics)?<\/strong><br>It may <strong>reduce the effect<\/strong> of <strong>antihypertensives<\/strong> (including ACE inhibitors and beta-blockers) and <strong>diuretics<\/strong>, and diuretics may <strong>increase kidney risk<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>9) Can I combine it with other painkillers like aspirin or another NSAID?<\/strong><br>Using <strong>two or more NSAIDs<\/strong> together may <strong>increase side effects<\/strong>; it is <strong>not recommended<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>10) Does it contain lactose?<\/strong><br>Yes. It <strong>contains lactose monohydrate<\/strong> and should <strong>not<\/strong> be used by people with <strong>galactose intolerance, Lapp lactase deficiency,<\/strong> or <strong>glucose-galactose malabsorption<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>11) I\u2019m on warfarin or an SSRI \u2014 is that a problem?<\/strong><br>Ibuprofen may <strong>enhance the effects of anticoagulants<\/strong> (e.g., warfarin) and, with <strong>SSRIs<\/strong>, may <strong>increase <a href=\"https:\/\/rxquora.com\/en\/hyospasmol-tablets-uses-side-effects-precautions\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/hyospasmol-tablets-uses-side-effects-precautions\/\">GI bleeding risk<\/a><\/strong>. Discuss with a healthcare professional.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>12) What should I do if I notice black stools or vomit blood?<\/strong><br><strong>Stop<\/strong> the medicine. These can indicate <strong>GI bleeding<\/strong>, which is a <strong>serious side effect<\/strong>. <strong>Seek medical advice urgently.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>It is a film-coated tablet used to relieve mild to moderate pain of inflammatory origin and to reduce fever. It is suitable for short-term use in adults and adolescents from 12 years and older. The medicine belongs to the non-steroidal anti-inflammatory drug (NSAID) group and offers pain-relief, anti-inflammatory and fever-reducing actions. What it is and &#8230; <a title=\"BRUFEN 400 : Uses,Side Effects,Warnings,Precautions\" class=\"read-more\" href=\"https:\/\/rxquora.com\/en\/brufen-400-uses-side-effects-warnings-precautions\/\" aria-label=\"Read more about BRUFEN 400 : Uses,Side Effects,Warnings,Precautions\">Read more<\/a><\/p>\n","protected":false},"author":3,"featured_media":2457,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[38],"tags":[],"class_list":["post-2111","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-first-aid"],"_links":{"self":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/posts\/2111","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/comments?post=2111"}],"version-history":[{"count":0,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/posts\/2111\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/media\/2457"}],"wp:attachment":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/media?parent=2111"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/categories?post=2111"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/tags?post=2111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}