{"id":2113,"date":"2025-09-23T12:15:39","date_gmt":"2025-09-23T10:15:39","guid":{"rendered":"https:\/\/rxquora.com\/en\/?p=2113"},"modified":"2025-09-23T12:16:23","modified_gmt":"2025-09-23T10:16:23","slug":"espiride-uses-side-effects-warnings-precautions","status":"publish","type":"post","link":"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/","title":{"rendered":"ESPIRIDE : Uses,Side Effects,Warnings,Precautions"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>It<\/strong> is a South African Schedule 5 medicine that contains <strong>sulpiride<\/strong>, available as capsules and as an oral <strong>elixir<\/strong>.It is used mainly for <strong>schizophrenia<\/strong>, certain <strong>depressive conditions<\/strong>, <strong>acute confusional states<\/strong>, specific <strong>behavioural disorders<\/strong>, and as an <strong>adjunct<\/strong> in duodenal ulceration of psychosomatic origin. It is also used to treat <strong>vertigo<\/strong>, and has <strong>anti-emetic<\/strong> (anti-nausea) effects.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_it_is_and_what_it_is_used_for\"><\/span>What it is and what it is used for<span class=\"ez-toc-section-end\"><\/span><\/h2><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/#What_it_is_and_what_it_is_used_for\" >What it is and what it is used for<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/#How_it_works\" >How it works<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/#Who_should_NOT_use_this_medicine\" >Who should NOT use this medicine<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/#Warnings_and_precautions_Read_before_use\" >Warnings and precautions (Read before use)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/#Pregnancy_planning_pregnancy_and_breastfeeding\" >Pregnancy, planning pregnancy, and breastfeeding<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/#Interactions\" >Interactions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/#How_to_take_Step-by-step\" >How to take (Step-by-step)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/#Dosing_table\" >Dosing table<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/#Possible_side_effects\" >Possible side effects<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/#Side_effects_reported\" >Side effects reported<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/#Serious%E2%80%94seek_urgent_help\" >Serious\u2014seek urgent help<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/#Storage_and_disposal\" >Storage and disposal<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/#What_the_medicine_contains\" >What the medicine contains<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/#Pack_information_and_appearance\" >Pack information and appearance<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/#FAQs\" >FAQs<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n\n<p class=\"wp-block-paragraph\"><strong>What it is<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ESPIRIDE contains <strong>sulpiride<\/strong>, described as a substituted benzamide listed under tranquillisers (miscellaneous). It exerts <strong>antipsychotic<\/strong> and <strong>anti-emetic<\/strong> actions and influences <strong>gastrin<\/strong> secretion .<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>What it is used for <\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Reactive depression<\/strong> and depression associated with psychoses of other origins; <strong>prophylaxis and treatment of depressive psychoses<\/strong>.<\/li>\n\n\n\n<li><strong>Schizophrenia<\/strong>, particularly where <strong>hallucinations, autism, aggressiveness<\/strong>, or <strong>withdrawn\u2013inhibited<\/strong> features are present.<\/li>\n\n\n\n<li><strong>Acute delirium<\/strong>, <strong>acute hallucinatory<\/strong> states, and <strong>confused states<\/strong>.<\/li>\n\n\n\n<li><strong>Behaviour disorders in all age groups<\/strong> where <strong>abnormal aggressive symptoms<\/strong> are prominent.<\/li>\n\n\n\n<li>As a <strong>useful adjunct<\/strong> in the medical treatment of <strong>duodenal ulceration of psychosomatic origin<\/strong>.<\/li>\n\n\n\n<li><strong>Vertigo<\/strong> treatment.<\/li>\n\n\n\n<li><strong>Anti-emetic<\/strong> action.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_it_works\"><\/span>How it works <span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The source states that sulpiride has <strong>antipsychotic<\/strong> and <strong>anti-emetic<\/strong> actions and affects <strong>gastrin secretion<\/strong>. In everyday terms, it helps <strong>steady disordered thinking and perception<\/strong>, reduces <strong>nausea<\/strong>, and influences a stomach hormone (<strong>gastrin<\/strong>). It is <strong>absorbed<\/strong> when taken by mouth, and its effects are related to a <strong>half-life of about 7\u20139 hours<\/strong>, which guides dosing frequency.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Who_should_NOT_use_this_medicine\"><\/span>Who should NOT use this medicine<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Do not use ESPIRIDE if any of the following apply<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>You are <strong>hypersensitive\/allergic<\/strong> to <strong>sulpiride<\/strong> or <strong>phenothiazines<\/strong>.<\/li>\n\n\n\n<li>You have a <strong>phaeochromocytoma<\/strong>.<\/li>\n\n\n\n<li>You have <strong>bone-marrow depression<\/strong>.<\/li>\n\n\n\n<li>You are <strong>hypomanic<\/strong>, in the <strong>manic<\/strong> or <strong>pre-manic<\/strong> phase of <strong>manic-depressive psychosis<\/strong>, or you have <strong>acute mania<\/strong> (ESPIRIDE may <strong>exacerbate<\/strong> symptoms).<\/li>\n\n\n\n<li>You have <strong>acute porphyria<\/strong> (ESPIRIDE is considered <strong>unsafe<\/strong>).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Special excipient-related exclusions :<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Capsules<\/strong>: contain <strong>lactose monohydrate<\/strong>. Patients with <strong>rare hereditary conditions of galactose intolerance<\/strong> (e.g., <strong>galactosaemia<\/strong>, <strong>Lapp lactase deficiency<\/strong>, <strong>glucose-galactose malabsorption<\/strong>) or <strong>fructose intolerance<\/strong> should <strong>not<\/strong> take ESPIRIDE.<\/li>\n\n\n\n<li><strong>Elixir<\/strong>: patients with <strong>sorbitol intolerance<\/strong> should <strong>not<\/strong> take <strong>ESPIRIDE ELIXIR<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Pregnancy<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The <strong>safety in pregnancy has not been established<\/strong> (see section on pregnancy for details).<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Warnings_and_precautions_Read_before_use\"><\/span>Warnings and precautions (Read before use)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>General cautions<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Tapering:<\/strong> <strong>Slowly decrease<\/strong> the dosage before <strong>total withdrawal<\/strong>.<\/li>\n\n\n\n<li><strong>Cardiovascular\/respiratory disease:<\/strong> Use with <strong>caution<\/strong>, particularly where a <strong>sudden drop in blood pressure<\/strong> would be risky. Dose adjustments may be needed if you are taking other medicines that cause <strong>postural hypotension<\/strong> (drop in blood pressure when standing).<\/li>\n\n\n\n<li><strong>Heart conditions:<\/strong> Use with care in <strong>existing tachycardia<\/strong> or <strong>cardiac insufficiency<\/strong>.<\/li>\n\n\n\n<li><strong>Liver:<\/strong> Use with care in <strong>liver dysfunction<\/strong> or a <strong>history of jaundice<\/strong>.<\/li>\n\n\n\n<li><strong>Parkinsonism:<\/strong> Use with care (see Interactions).<\/li>\n\n\n\n<li><strong>Seizure risk:<\/strong> <strong>Care is required<\/strong> if you are on <strong>anticonvulsant therapy<\/strong>; ESPIRIDE may <strong>lower the convulsive threshold<\/strong> (see Interactions).<\/li>\n\n\n\n<li><strong>Elderly\/debilitated:<\/strong> Use with <strong>care<\/strong>; <strong>reduced doses<\/strong> are recommended in the <strong>elderly<\/strong>.<\/li>\n\n\n\n<li><strong>Eye\/skin monitoring:<\/strong> During <strong>long-term therapy<\/strong>, have <strong>regular examinations<\/strong> for <strong>abnormal pigmentation<\/strong> or <strong>ocular changes<\/strong>.<\/li>\n\n\n\n<li><strong>Diabetes:<\/strong> The <strong>capsules<\/strong> contain <strong>lactose<\/strong>, which may affect <strong>glycaemic control<\/strong> in patients with <strong>diabetes mellitus<\/strong>.<\/li>\n\n\n\n<li><strong>Gastrointestinal warning:<\/strong> The <strong>anti-emetic action<\/strong> may <strong>mask symptoms<\/strong> of conditions such as <strong>gastrointestinal obstruction<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Driving and using machines<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ESPIRIDE may cause <strong>drowsiness<\/strong> and <strong>impaired concentration<\/strong>. These effects can be <strong>aggravated<\/strong> by <strong>alcohol<\/strong> or other <strong>central nervous system depressants<\/strong>. <strong>Do not drive<\/strong>, operate <strong>hazardous machinery<\/strong>, or perform <strong>dangerous tasks<\/strong> if affected.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Blood disorders<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The source reports <strong>various haematological disorders<\/strong>, including <strong>haemolytic anaemia<\/strong>, <strong>aplastic anaemia<\/strong>, <strong>thrombocytopenic purpura<\/strong>, and a <strong>potentially fatal agranulocytosis<\/strong>.<\/li>\n\n\n\n<li><strong>Important:<\/strong> Many cases of <strong>agranulocytosis<\/strong> occurred within <strong>4\u201310 weeks<\/strong> of starting treatment. If you develop <strong>sore throat<\/strong> or <strong>fever<\/strong>, seek medical advice urgently; <strong>white cell counts<\/strong> should be checked if these symptoms appear.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Temperature regulation<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ESPIRIDE can <strong>impair body temperature regulation<\/strong>, leading to <strong>hypothermia<\/strong> or <strong>hyperthermia<\/strong> depending on the environment.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Endocrine\/metabolic<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The source notes <strong>hyperglycaemia<\/strong>, <strong>altered glucose tolerance<\/strong>, and <strong>increased serum-cholesterol concentrations<\/strong> in some patients.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Alcohol content and sweeteners (Elixir)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Elixir contains alcohol (5,0% v\/v)<\/strong> as well as <strong>sorbitol<\/strong> and sweeteners (<strong>sodium cyclamate<\/strong> and <strong>saccharin sodium<\/strong>). See Interactions and excipient cautions.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pregnancy_planning_pregnancy_and_breastfeeding\"><\/span>Pregnancy, planning pregnancy, and breastfeeding<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Not specified in the source<\/strong> beyond: <strong>\u201cThe safety in pregnancy has not been established.\u201d<\/strong><\/li>\n\n\n\n<li><strong>Advice:<\/strong> <strong>Speak to your doctor or pharmacist before use<\/strong> if you are pregnant, planning a pregnancy, or breastfeeding.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Interactions\"><\/span>Interactions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Levodopa (and other anti-Parkinson medicines):<\/strong> The <strong>anti-Parkinsonian actions<\/strong> (e.g., of <strong>levodopa<\/strong>) may be <strong>diminished<\/strong> by ESPIRIDE.<\/li>\n\n\n\n<li><strong>Sucralfate\/antacids (aluminium\/magnesium hydroxides):<\/strong> These <strong>reduce ESPIRIDE bioavailability<\/strong>. If needed together, <strong>take ESPIRIDE before<\/strong> (rather than with or after) <strong>sucralfate\/antacids<\/strong>.<\/li>\n\n\n\n<li><strong>Atropine and tricyclic antidepressants:<\/strong> ESPIRIDE may <strong>enhance anticholinergic properties<\/strong>.<\/li>\n\n\n\n<li><strong>Medicines that may cause leucopenia:<\/strong> Do <strong>not<\/strong> combine with agents such as <strong>phenylbutazone<\/strong> and <strong>thiouracils<\/strong>.<\/li>\n\n\n\n<li><strong>Adrenergic neuron blockers (e.g., guanethidine):<\/strong> ESPIRIDE may <strong>reduce antihypertensive action<\/strong>.<\/li>\n\n\n\n<li><strong>Central nervous system depressants:<\/strong> ESPIRIDE <strong>enhances<\/strong> the activity of <strong>alcohol<\/strong>, <strong>anaesthetics<\/strong>, <strong>hypnotics<\/strong>, and <strong>narcotic analgesics<\/strong>; <strong>dose reductions<\/strong> of those agents may be required.<\/li>\n\n\n\n<li><strong>Anticonvulsants (e.g., diazepam, phenobarbitone, phenytoin):<\/strong> ESPIRIDE does <strong>not<\/strong> enhance their anticonvulsant effects and may <strong>lower the convulsive threshold<\/strong>.<\/li>\n\n\n\n<li><strong>Clinical masking:<\/strong> Its <strong>anti-emetic action<\/strong> may <strong>mask<\/strong> signs of disorders like <strong>gastrointestinal obstruction<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Practical tip <\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>If you must use ESPIRIDE with <strong>sucralfate<\/strong> or <strong>antacids<\/strong>, <strong>take ESPIRIDE first<\/strong>.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_to_take_Step-by-step\"><\/span>How to take (Step-by-step)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>Important:<\/strong> The following is copied in meaning (not wording) from the professional information. <strong>Do not change your dose without medical advice.<\/strong><\/p>\n<\/blockquote>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>For schizophrenia (Adults):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Initial dose:<\/strong> <strong>200\u2013400 mg twice daily<\/strong>.<\/li>\n\n\n\n<li><strong>If needed:<\/strong> May be increased to a <strong>maximum of 1,2 g twice daily<\/strong>.<\/li>\n\n\n\n<li><strong>Maintenance:<\/strong> <strong>600\u2013800 mg per day<\/strong> in <strong>divided doses<\/strong>, continued <strong>as long as necessary<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>For common, milder psychiatric conditions of shorter duration and behavioural disorders (Adults):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>100\u2013200 mg daily<\/strong>, up to <strong>300 mg per day<\/strong> in <strong>divided doses<\/strong>.<\/li>\n\n\n\n<li>For <strong>maintenance<\/strong>, <strong>reduce or increase as necessary<\/strong> (as per clinical response).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Children (6\u201312 years) with behavioural disorders (from the source group):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>3\u20135 mg\/kg body mass per day<\/strong> in <strong>divided doses<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>For gastro-enterology (Adults):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>150\u2013300 mg daily<\/strong> in <strong>divided doses<\/strong>.<\/li>\n\n\n\n<li><strong>Maintenance and duration<\/strong> according to <strong>patient\u2019s requirements<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>For vertigo (Adults):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>150\u2013300 mg daily<\/strong> in <strong>divided doses<\/strong>, depending on intensity of vertigo.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Elderly:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Use <strong>reduced doses<\/strong> (no specific amounts provided in the source).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Tapering\/Stopping:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Slowly decrease<\/strong> the <strong>dosage<\/strong> before <strong>totally withdrawing<\/strong> ESPIRIDE.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>With or without food:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Not specified in the source.<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Missed dose:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Not specified in the source.<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Overdose :<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Symptoms:<\/strong> See <strong>Side effects<\/strong> section.<\/li>\n\n\n\n<li><strong>Treatment:<\/strong> In <strong>severe overdosage<\/strong>, the <strong>stomach should be emptied by aspiration and lavage<\/strong>. <strong>Emetics should not be used<\/strong>. Ongoing management is <strong>symptomatic and supportive<\/strong>.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dosing_table\"><\/span>Dosing table <span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Indication \/ Setting<\/th><th>Population<\/th><th>Dose<\/th><th>Frequency<\/th><th>Notes \/ Maximum<\/th><\/tr><\/thead><tbody><tr><td><strong>Schizophrenia (initial)<\/strong><\/td><td>Adults<\/td><td>200\u2013400 mg<\/td><td>Twice daily<\/td><td>May increase if needed<\/td><\/tr><tr><td><strong>Schizophrenia (maximum during titration)<\/strong><\/td><td>Adults<\/td><td>Up to <strong>1,2 g<\/strong><\/td><td>Twice daily<\/td><td>As per source \u201cmaximum of 1,2 g twice daily\u201d<\/td><\/tr><tr><td><strong>Schizophrenia (maintenance)<\/strong><\/td><td>Adults<\/td><td><strong>600\u2013800 mg\/day<\/strong><\/td><td>Divided doses<\/td><td>Continue as long as necessary<\/td><\/tr><tr><td><strong>Milder psychiatric conditions \/ behavioural disorders<\/strong><\/td><td>Adults<\/td><td>100\u2013200 mg\/day (up to <strong>300 mg\/day<\/strong>)<\/td><td>Divided doses<\/td><td>Adjust for maintenance as necessary<\/td><\/tr><tr><td><strong>Behavioural disorders<\/strong><\/td><td>Children 6\u201312 years<\/td><td><strong>3\u20135 mg\/kg\/day<\/strong><\/td><td>Divided doses<\/td><td>\u2013<\/td><\/tr><tr><td><strong>Gastro-enterology<\/strong><\/td><td>Adults<\/td><td><strong>150\u2013300 mg\/day<\/strong><\/td><td>Divided doses<\/td><td>Maintenance &amp; duration as required<\/td><\/tr><tr><td><strong>Vertigo<\/strong><\/td><td>Adults<\/td><td><strong>150\u2013300 mg\/day<\/strong><\/td><td>Divided doses<\/td><td>Depending on intensity<\/td><\/tr><tr><td><strong>Elderly<\/strong><\/td><td>Older adults<\/td><td><strong>Reduced doses<\/strong><\/td><td>\u2013<\/td><td>Exact amounts <strong>not specified<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Possible_side_effects\"><\/span>Possible side effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The <a href=\"https:\/\/rxquora.com\/en\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/\">professional information<\/a> lists the following unwanted effects.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Side_effects_reported\"><\/span>Side effects reported <span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Neurological\/extrapyramidal:<\/strong> Mild <strong>sedation<\/strong>; <strong>extrapyramidal disorders<\/strong> including <strong>acute dystonia<\/strong>, <strong>Parkinsonism-like syndrome<\/strong>, <strong>akathisia<\/strong>, and <strong>neuroleptic malignant syndrome<\/strong>; <strong>tardive dyskinesia<\/strong>; <strong>perioral tremor<\/strong>; <strong>sleep disturbances<\/strong>; <strong>overstimulation<\/strong>; <strong>agitation<\/strong>; <strong>insomnia<\/strong>; <strong>depression<\/strong>; <strong>convulsions<\/strong>.<\/li>\n\n\n\n<li><strong>Cardiovascular:<\/strong> <strong>Hypertension<\/strong>, <strong>tachycardia<\/strong>, <strong>cardiac arrhythmias<\/strong>, <strong>electrocardiographic changes<\/strong>, <strong>postural hypotension<\/strong>.<\/li>\n\n\n\n<li><strong>Endocrine\/metabolic:<\/strong> <strong>Impotence<\/strong>, <strong>amenorrhoea<\/strong>, <strong>galactorrhoea<\/strong>, <strong>gynaecomastia<\/strong>, <strong>mass gain<\/strong>; <strong>hyperglycaemia<\/strong>, <strong>altered glucose tolerance<\/strong>, <strong>increased serum-cholesterol<\/strong>.<\/li>\n\n\n\n<li><strong>Gastrointestinal\/antimuscarinic-type:<\/strong> <strong>Dry mouth<\/strong>, <strong>constipation<\/strong>, <strong>urinary retention<\/strong>, <strong>mydriasis<\/strong> (pupil dilation).<\/li>\n\n\n\n<li><strong>Respiratory\/ENT:<\/strong> <strong>Nasal congestion<\/strong>; <strong>blurred vision<\/strong> (listed under antimuscarinic effects).<\/li>\n\n\n\n<li><strong>Hepatic:<\/strong> <strong>Minor abnormalities<\/strong> in <strong>liver function tests<\/strong>; <strong>jaundice<\/strong> (reported, probably allergic in origin).<\/li>\n\n\n\n<li><strong>Allergic\/skin &amp; eyes:<\/strong> <strong>Urticaria<\/strong>, <strong>exfoliative dermatitis<\/strong>, <strong>erythema multiforme<\/strong>, <strong>contact sensitivity<\/strong>; <strong>photosensitivity<\/strong> reactions; <strong>pigment deposition<\/strong> in <strong>skin<\/strong> and more often <strong>eyes<\/strong> with <strong>corneal and lens opacities<\/strong> (with prolonged therapy).<\/li>\n\n\n\n<li><strong>Haematological:<\/strong> <strong>Haemolytic anaemia<\/strong>, <strong>aplastic anaemia<\/strong>, <strong>thrombocytopenic purpura<\/strong>, <strong>agranulocytosis<\/strong> (potentially <strong>fatal<\/strong>; many cases within <strong>4\u201310 weeks<\/strong> of starting).<\/li>\n\n\n\n<li><strong>Thermoregulation:<\/strong> <strong>Hypo- or hyperthermia<\/strong> depending on environment.<\/li>\n\n\n\n<li><strong>Withdrawal after high doses:<\/strong> <strong>Nausea<\/strong>, <strong>vomiting<\/strong>, <strong>gastritis<\/strong>, <strong>tremors<\/strong> on abrupt discontinuation.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Serious%E2%80%94seek_urgent_help\"><\/span>Serious\u2014seek urgent help <span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Neuroleptic malignant syndrome<\/strong>.<\/li>\n\n\n\n<li><strong>Agranulocytosis<\/strong> (especially if you develop <strong>fever<\/strong> or <strong>sore throat<\/strong> within <strong>4\u201310 weeks<\/strong> of starting).<\/li>\n\n\n\n<li><strong>Cardiac arrhythmias<\/strong> or significant <strong>postural hypotension<\/strong>.<\/li>\n\n\n\n<li><strong>Jaundice<\/strong> (yellowing of the skin\/eyes).<\/li>\n\n\n\n<li><strong>Severe allergic skin reactions<\/strong> (e.g., <strong>exfoliative dermatitis<\/strong>, <strong>erythema multiforme<\/strong>).<\/li>\n\n\n\n<li><strong>Corneal or lens opacities<\/strong> and <strong>abnormal ocular pigmentation<\/strong> noted on examinations.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>What to do:<\/strong> If you notice any severe reaction or worrying symptoms mentioned above, <strong>stop taking ESPIRIDE and seek urgent medical care<\/strong>. For <strong>fever<\/strong> or <strong>sore throat<\/strong>, arrange <strong>white cell counts<\/strong> as directed in the source.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Storage_and_disposal\"><\/span>Storage and disposal<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Store at or below 25 \u00b0C<\/strong>.<\/li>\n\n\n\n<li><strong>Protect from light and moisture<\/strong>.<\/li>\n\n\n\n<li><strong>Keep in the original packaging<\/strong> until needed.<\/li>\n\n\n\n<li><strong>Keep out of the reach of children<\/strong>.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_the_medicine_contains\"><\/span>What the medicine contains<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Capsules<\/strong> (ESPIRIDE capsules):<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Active:<\/strong> <strong>Sulpiride 50 mg<\/strong> per capsule.<\/li>\n\n\n\n<li><strong>Excipients (from source):<\/strong> Colloidal silicon dioxide, gelatin, <strong>lactose monohydrate<\/strong> (contains sugar; <strong>112 mg<\/strong> lactose per capsule), magnesium stearate, purified talc, maize starch, titanium dioxide (C.I. 77891).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Elixir<\/strong> (ESPIRIDE ELIXIR):<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Active:<\/strong> <strong>Sulpiride 25 mg per 5 ml<\/strong>.<\/li>\n\n\n\n<li><strong>Excipients (from source):<\/strong> <strong>Alcohol (5,0% v\/v)<\/strong>, disodium edetate, dye Lennon yellow (C.I. 47005), flavour lemon essence No.1, glycerol, <strong>saccharin sodium<\/strong>, <strong>sodium cyclamate<\/strong>, <strong>sorbitol (70%) solution<\/strong>, methyl hydroxybenzoate, propyl hydroxybenzoate, purified water.<\/li>\n\n\n\n<li><strong>Preservatives (from source):<\/strong> <strong>Methyl hydroxybenzoate 0,08% m\/v<\/strong>, <strong>propyl hydroxybenzoate 0,02% m\/v<\/strong>.<\/li>\n\n\n\n<li><strong>Contains sugar\/sweeteners:<\/strong> <strong>Sorbitol 26,058 mg<\/strong> (per 5 ml), <strong>sodium cyclamate 55 mg<\/strong>, <strong>saccharin sodium 2,5 mg<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Excipient cautions:<\/strong> See \u201cWho should NOT use this medicine\u201d for <strong>lactose<\/strong>, <strong>sorbitol<\/strong>, <strong>sweetener<\/strong>, and <strong>alcohol<\/strong> warnings that are specified in the source.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pack_information_and_appearance\"><\/span>Pack <a href=\"https:\/\/rxquora.com\/en\/anaerobyl-metronidazole-uses-side-effects-precautions-and-dosage-information\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/anaerobyl-metronidazole-uses-side-effects-precautions-and-dosage-information\/\">information<\/a> and appearance<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Identification <\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ESPIRIDE capsules:<\/strong> White powder in a No. 3 <strong>off-white, opaque capsule<\/strong>, printed with a <strong>mortar and pestle<\/strong> and <strong>\u201cLennon\u201d<\/strong> in blue ink.<\/li>\n\n\n\n<li><strong>ESPIRIDE ELIXIR:<\/strong> <strong>Clear, bright, yellowish-green solution<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Presentation <\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Capsules:<\/strong> Packs of <strong>100 capsules<\/strong> in various securitainers; <strong>28<\/strong> or <strong>56 capsules<\/strong> in Ziploc metallised lay-flat bags (grouped into polyethylene bags).<\/li>\n\n\n\n<li><strong>Elixir:<\/strong> <strong>100 ml<\/strong> bottles (various materials and caps) supplied in an <strong>outer cardboard carton<\/strong>.<\/li>\n\n\n\n<li><strong>Note:<\/strong> <strong>Not all packs and pack sizes are necessarily marketed.<\/strong><\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FAQs\"><\/span>FAQs<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1) What scheduling status does ESPIRIDE have in South Africa?<\/strong><br>It is listed as <strong>S5<\/strong> in the professional information.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2) What strengths and forms are available?<\/strong><br><strong>Capsules<\/strong> with <strong>50 mg<\/strong> sulpiride each; <strong>elixir<\/strong> containing <strong>25 mg per 5 ml<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3) Can I drive or operate machinery while taking ESPIRIDE?<\/strong><br>Use <strong>caution<\/strong>. It may cause <strong>drowsiness<\/strong> and <strong>impaired concentration<\/strong>, which are worse with <strong>alcohol<\/strong> or other <strong>CNS depressants<\/strong>. <strong>Do not<\/strong> drive or operate hazardous machinery if affected.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4) Does the elixir contain alcohol or sweeteners?<\/strong><br>Yes. The <strong>elixir contains alcohol (5,0% v\/v)<\/strong>, <strong>sorbitol<\/strong>, <strong>sodium cyclamate<\/strong>, and <strong>saccharin sodium<\/strong> (amounts are listed in the source).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>5) I take antacids or sucralfate\u2014how should I time ESPIRIDE?<\/strong><br><strong>ESPIRIDE bioavailability is reduced<\/strong> with <strong>sucralfate\/antacids<\/strong>. If used together, <strong>take ESPIRIDE before<\/strong> (rather than with or after) these agents.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>6) Can I take ESPIRIDE with levodopa for Parkinson\u2019s disease?<\/strong><br>The source states that the <strong>anti-Parkinsonian actions<\/strong> of agents like <strong>levodopa<\/strong> may be <strong>diminished<\/strong> by ESPIRIDE. Discuss with your doctor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>7) Do I need to taper off ESPIRIDE?<\/strong><br>Yes. The source advises a <strong>slow decrease<\/strong> in dose before <strong>total withdrawal<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>8) Is ESPIRIDE safe in pregnancy or breastfeeding?<\/strong><br>The <strong>safety in pregnancy has not been established<\/strong>. <strong>Speak to your doctor or pharmacist before use.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>9) Are there people who must not take ESPIRIDE because of the excipients?<\/strong><br>Yes. <strong>Capsules<\/strong> should <strong>not<\/strong> be used by patients with <strong>galactose intolerance<\/strong> conditions (e.g., <strong>galactosaemia<\/strong>, <strong>Lapp lactase deficiency<\/strong>, <strong>glucose-galactose malabsorption) or fructose intolerance<\/strong> (per source wording). The <strong>elixir<\/strong> should <strong>not<\/strong> be used in <strong>sorbitol intolerance<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>10) Is ESPIRIDE used for vertigo and duodenal ulcers?<\/strong><br>Yes. The source lists use in <strong>vertigo<\/strong> (adults <strong>150\u2013300 mg\/day<\/strong> in divided doses) and as a <strong>useful adjunct<\/strong> in the medical <a href=\"https:\/\/rxquora.com\/en\/depression-symptoms-test-causes-and-treatment\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/depression-symptoms-test-causes-and-treatment\/\">treatment<\/a> of <strong>duodenal ulceration of psychosomatic origin<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>It is a South African Schedule 5 medicine that contains sulpiride, available as capsules and as an oral elixir.It is used mainly for schizophrenia, certain depressive conditions, acute confusional states, specific behavioural disorders, and as an adjunct in duodenal ulceration of psychosomatic origin. It is also used to treat vertigo, and has anti-emetic (anti-nausea) effects. &#8230; <a title=\"ESPIRIDE : Uses,Side Effects,Warnings,Precautions\" class=\"read-more\" href=\"https:\/\/rxquora.com\/en\/espiride-uses-side-effects-warnings-precautions\/\" aria-label=\"Read more about ESPIRIDE : Uses,Side Effects,Warnings,Precautions\">Read more<\/a><\/p>\n","protected":false},"author":5,"featured_media":2391,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[],"class_list":["post-2113","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicines"],"_links":{"self":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/posts\/2113","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/comments?post=2113"}],"version-history":[{"count":0,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/posts\/2113\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/media\/2391"}],"wp:attachment":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/media?parent=2113"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/categories?post=2113"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/tags?post=2113"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}