{"id":2138,"date":"2025-09-19T19:13:51","date_gmt":"2025-09-19T17:13:51","guid":{"rendered":"https:\/\/rxquora.com\/en\/?p=2138"},"modified":"2025-09-21T11:37:45","modified_gmt":"2025-09-21T09:37:45","slug":"bemetrazole-uses-dose-side-effects-precautions","status":"publish","type":"post","link":"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/","title":{"rendered":"BEMETRAZOLE: Uses,Dose,Side-Effects,Precautions"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>BEMETRAZOLE<\/strong> (metronidazole) is an antibiotic and antiprotozoal medicine used to <strong>treat certain bacterial infections<\/strong> and to <strong>help prevent infection after surgery<\/strong>. It is available as tablets in two strengths: <strong>200 mg<\/strong> and <strong>400 mg<\/strong> of metronidazole. In South Africa, it is a <strong>Schedule 4 (S4)<\/strong> medicine, which means it is available on prescription only and should be taken exactly as directed by a healthcare professional.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">BEMETRAZOLE works by <strong>killing the germs<\/strong> (bacteria and some parasites) that are causing infection in the body. It is often used alone, but for some infections your doctor may prescribe it <strong>together with other appropriate antibiotics<\/strong>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_it_is_and_what_it_is_used_for\"><\/span>What it is and what it is used for<span class=\"ez-toc-section-end\"><\/span><\/h2><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#What_it_is_and_what_it_is_used_for\" >What it is and what it is used for<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#How_it_works\" >How it works<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#Who_should_NOT_use_this_medicine\" >Who should NOT use this medicine<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#Warnings_and_precautions\" >Warnings and precautions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#Pregnancy_planning_pregnancy_and_breastfeeding\" >Pregnancy, planning pregnancy, and breastfeeding<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#Interactions\" >Interactions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#How_to_take_Step-by-step\" >How to take (Step-by-step)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#Anaerobic_infections\" >Anaerobic infections<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#Helicobacter_pylori-associated_gastritis_and_duodenal_ulcer_used_in_combination_regimens\" >Helicobacter pylori-associated gastritis and duodenal ulcer (used in combination regimens)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#Dosing_table\" >Dosing table<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#Possible_side_effects\" >Possible side effects<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#Serious_%E2%80%94_seek_urgent_help\" >Serious \u2014 seek urgent help<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#Common\" >Common<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#Less_common\" >Less common<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#Additional_side_effects\" >Additional side effects<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#Storage_and_disposal\" >Storage and disposal<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#What_the_medicine_contains\" >What the medicine contains<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#Pack_information_and_appearance\" >Pack information and appearance<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/#FAQs\" >FAQs<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n\n<p class=\"wp-block-paragraph\">BEMETRAZOLE contains <strong>metronidazole<\/strong>, an <strong>antimicrobial<\/strong> agent that fights certain <strong>bacteria<\/strong> and <strong>parasites<\/strong>. It is used:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>To treat infections caused by certain bacteria.<\/strong><\/li>\n\n\n\n<li><strong>To prevent infections after surgery.<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Note:<\/strong> For some conditions, your doctor may combine metronidazole with other antibiotics that target a wider range of germs.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_it_works\"><\/span>How it works <span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Metronidazole gets inside susceptible bacteria and parasites and <strong>disrupts their DNA<\/strong>, which <strong>stops them from growing and reproducing<\/strong>. As a result, the germs die and the infection clears. You may start to feel better before the course ends, but <strong>finishing the full course<\/strong> is important to fully clear the infection and reduce the risk of it coming back.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Who_should_NOT_use_this_medicine\"><\/span>Who should NOT use this medicine<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Do not take BEMETRAZOLE if:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>You are <strong>allergic<\/strong> (hypersensitive) to metronidazole or any of the ingredients in the tablet.\n<ul class=\"wp-block-list\">\n<li>Signs of allergy include <strong>rash<\/strong>, <strong>itchy hives<\/strong>, <strong>trouble breathing or swallowing<\/strong>, or <strong>swelling of the lips, face, throat, or tongue<\/strong>.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>You have a <strong>blood disease or blood disorder<\/strong>.<\/li>\n\n\n\n<li>You are taking <strong>busulfan<\/strong> (a cancer medicine used for blood cell cancers).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">If any of the above apply, or if you are not sure, <strong>speak to your doctor or pharmacist before taking BEMETRAZOLE<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Warning:<\/strong> Never share your prescription with another person, even if their symptoms seem similar. It may harm them.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Warnings_and_precautions\"><\/span>Warnings and precautions <span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Tell your doctor before starting BEMETRAZOLE and take special care if any of the following apply:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Liver problems and brain effects from liver disease:<\/strong>\n<ul class=\"wp-block-list\">\n<li>If you have <strong>hepatic encephalopathy<\/strong> (reduced brain function due to severe liver disease), you require careful medical supervision.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Cockayne syndrome:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>Severe liver toxicity or acute liver failure<\/strong> has been reported with systemic metronidazole in patients with <strong>Cockayne syndrome<\/strong> (a rare neurodegenerative disorder).<\/li>\n\n\n\n<li>Patients with Cockayne syndrome should <strong>stop metronidazole and contact a doctor immediately<\/strong> if any symptoms of liver injury appear.<\/li>\n\n\n\n<li><strong>Liver function tests<\/strong> should be performed during treatment and until liver values return to normal. If liver tests rise, <strong>metronidazole should be discontinued<\/strong>.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Effect on syphilis tests:<\/strong>\n<ul class=\"wp-block-list\">\n<li>Metronidazole has <strong>anti-treponemal activity<\/strong> and <strong>may mask the immune response<\/strong> in untreated syphilis.<\/li>\n\n\n\n<li><strong>Contacts of syphilis<\/strong> receiving metronidazole should <strong>probably be screened again<\/strong> for <strong>4 to 8 weeks<\/strong>.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Possible persistent gonorrhoea:<\/strong>\n<ul class=\"wp-block-list\">\n<li>After <strong>Trichomonas vaginalis<\/strong> is treated and eliminated, a <strong>gonococcal infection may persist<\/strong>. Follow-up testing may be needed.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Severe gut infection risk:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>Pseudomembranous colitis<\/strong> (a serious colon infection) has been reported with metronidazole. Tell your doctor urgently if you develop <strong>watery, severe or bloody diarrhoea<\/strong>.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Alcohol:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>Do not drink alcohol<\/strong> (including medicines containing alcohol) while taking BEMETRAZOLE and for <strong>1 to 3 days after<\/strong> finishing. Combining alcohol with metronidazole may cause <strong>nausea, vomiting, stomach pain, flushing, palpitations, and headache<\/strong>.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Busulfan combination risk:<\/strong>\n<ul class=\"wp-block-list\">\n<li>Co-administration with <strong>busulfan<\/strong> can cause <strong>severe busulfan toxicity and may be fatal<\/strong> \u2014 this combination must be avoided.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Monitoring:<\/strong>\n<ul class=\"wp-block-list\">\n<li>If treatment lasts <strong>longer than 10 days<\/strong>, your doctor <strong>may carry out tests<\/strong>.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Driving and using machines<\/strong><br>BEMETRAZOLE can cause <strong>sleepiness, dizziness, confusion, hallucinations, fits (convulsions), and temporary eyesight problems<\/strong> (such as blurred or double vision). If affected, <strong>do not drive, cycle, or operate machinery<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Intolerance to sugars<\/strong><br>BEMETRAZOLE tablets contain <strong>lactose<\/strong>. If you have been told you are intolerant to some sugars, <strong>talk to your doctor before taking this medicine<\/strong>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pregnancy_planning_pregnancy_and_breastfeeding\"><\/span>Pregnancy, planning pregnancy, and breastfeeding<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The <strong>safety of BEMETRAZOLE in pregnancy and breastfeeding has not been established<\/strong>. Small amounts may pass into breast milk.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Not specified in the source. Speak to your doctor or pharmacist before use.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you are <strong>pregnant<\/strong>, <strong>might become pregnant<\/strong>, <strong>think you may be pregnant<\/strong>, or are <strong>breastfeeding<\/strong>, tell your doctor before using BEMETRAZOLE.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Interactions\"><\/span>Interactions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Always inform your healthcare professional about <strong>all<\/strong> medicines you take, including prescription, over-the-counter, complementary, or traditional medicines. The following interactions are noted in the source:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Disulfiram (for alcohol dependence):<\/strong> Taking with metronidazole can cause <strong>acute confusion<\/strong>.<\/li>\n\n\n\n<li><strong>Alcohol or alcohol-containing medicines:<\/strong> <strong>Avoid<\/strong> during treatment and for <strong>1\u20133 days after<\/strong> (see above).<\/li>\n\n\n\n<li><strong>Warfarin and other blood thinners:<\/strong> Metronidazole can <strong>intensify the effect<\/strong>, increasing the risk of <strong>uncontrolled bleeding<\/strong>.<\/li>\n\n\n\n<li><strong>Lithium (for mental health conditions):<\/strong> Metronidazole may <strong>increase lithium blood levels<\/strong>.<\/li>\n\n\n\n<li><strong>Phenytoin or phenobarbital (for epilepsy):<\/strong> These may <strong>reduce the effectiveness<\/strong> of metronidazole.<\/li>\n\n\n\n<li><strong>5-Fluorouracil (cancer treatment):<\/strong> Metronidazole may <strong>intensify harmful effects<\/strong> of 5-fluorouracil.<\/li>\n\n\n\n<li><strong>Busulfan (leukaemia):<\/strong> <strong>Do not combine<\/strong> \u2014 risk of <strong>severe toxicity and death<\/strong>.<\/li>\n\n\n\n<li><strong>Ciclosporin (post-transplant):<\/strong> Metronidazole may <strong>increase ciclosporin levels<\/strong>.<\/li>\n\n\n\n<li><strong>Cimetidine (stomach ulcers):<\/strong> May <strong>intensify the effects<\/strong> of metronidazole.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Practical tip:<\/strong> Do not start, stop, or change any medicine while on BEMETRAZOLE without medical advice.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_to_take_Step-by-step\"><\/span>How to take (Step-by-step)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>General directions<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Take BEMETRAZOLE <strong>exactly as your doctor has instructed<\/strong>.<\/li>\n\n\n\n<li><strong>Swallow tablets whole<\/strong> with a little water. <strong>Do not crush or chew.<\/strong><\/li>\n\n\n\n<li><strong>Take during or just after a meal.<\/strong><\/li>\n\n\n\n<li><strong>Finish the full course<\/strong>, even if you start feeling better. Stopping early may allow the infection to return.<\/li>\n\n\n\n<li>If the effect feels <strong>too strong or too weak<\/strong>, speak to your doctor or pharmacist.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Doses from the source<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Anaerobic_infections\"><\/span>Anaerobic infections<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>a) Treatment<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Adults:<\/strong>\n<ul class=\"wp-block-list\">\n<li>Initial dose: <strong>800 mg<\/strong> by mouth once, then <strong>400 mg every 8 hours<\/strong>.<\/li>\n\n\n\n<li>Duration: <strong>7 days or longer<\/strong>, depending on your doctor\u2019s clinical and laboratory assessments.<\/li>\n\n\n\n<li>May be given <strong>alone<\/strong> or <strong>with other appropriate antibacterial agents<\/strong>, as advised by your doctor.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Children and infants:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>7.5 mg per kg<\/strong> body mass by mouth <strong>every 8 hours<\/strong>, <strong>during or after meals<\/strong>.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>b) Prevention (pre-operative use)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Adults:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>400 mg every 8 hours<\/strong> in the <strong>24 hours before surgery<\/strong>, followed <strong>post-operatively by intravenous or rectal administration<\/strong> until oral therapy is possible.<\/li>\n\n\n\n<li>The source notes that <strong>shorter pre-operative courses<\/strong> and <strong>oral doses up to 1 g<\/strong> <strong>have been used<\/strong> (as guided by your doctor).<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Children:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>As for treatment (a)<\/strong> above (your doctor will calculate the dose by weight).<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Helicobacter_pylori-associated_gastritis_and_duodenal_ulcer_used_in_combination_regimens\"><\/span>Helicobacter pylori-associated gastritis and duodenal ulcer (used in combination regimens)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>BEMETRAZOLE 200\u2013250 mg<\/strong> <strong>4\u20135 times a day for 14 days<\/strong>, <strong>in combination with other medicines<\/strong> (your doctor will prescribe the full regimen).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Missed dose<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>If you <strong>forget a dose<\/strong>, take it <strong>as soon as you remember<\/strong>.<\/li>\n\n\n\n<li>If it is <strong>almost time for your next dose<\/strong>, <strong>skip<\/strong> the missed dose and take the next one at the usual time.<\/li>\n\n\n\n<li><strong>Do not<\/strong> take a <strong>double dose<\/strong> to make up for a missed dose.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Overdose<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>In case of suspected <strong>overdose<\/strong>, <strong>seek medical help immediately<\/strong>: contact your doctor, pharmacist, the nearest hospital, or a poison control centre.<\/li>\n\n\n\n<li><strong>Take the carton and bottle<\/strong> with you so healthcare providers know exactly what you took.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Monitoring during longer courses<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>If you use BEMETRAZOLE for <strong>more than 10 days<\/strong>, your doctor <strong>may order tests<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Note:<\/strong> The <strong>maximum daily dose<\/strong> is <strong>not specified in the source<\/strong>. Your doctor will tailor dosing to your condition.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dosing_table\"><\/span>Dosing table <span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p class=\"wp-block-paragraph\"><strong>Important:<\/strong> Doses below come directly from the source. If your doctor gives you a different schedule based on your condition, follow their advice.<\/p>\n<\/blockquote>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Indication<\/th><th>Age\/weight band<\/th><th>Dose<\/th><th>Frequency<\/th><th>When to take<\/th><th>Duration<\/th><th>Maximum daily dose<\/th><\/tr><\/thead><tbody><tr><td><strong>Anaerobic infections \u2013 Treatment (Adults)<\/strong><\/td><td>Adults<\/td><td>800 mg initial, then 400 mg<\/td><td>Every 8 hours<\/td><td>During or just after meals<\/td><td>7 days or longer, as directed<\/td><td><strong>Not specified in the source<\/strong><\/td><\/tr><tr><td><strong>Anaerobic infections \u2013 Treatment (Children\/Infants)<\/strong><\/td><td>By weight<\/td><td>7.5 mg\/kg<\/td><td>Every 8 hours<\/td><td>During or just after meals<\/td><td>As directed by doctor<\/td><td><strong>Not specified in the source<\/strong><\/td><\/tr><tr><td><strong>Anaerobic infections \u2013 Prevention (Adults)<\/strong><\/td><td>Adults<\/td><td>400 mg<\/td><td>Every 8 hours<\/td><td>As directed (pre-op oral dosing)<\/td><td>In the 24 hours <strong>before surgery<\/strong>, then <strong>IV or rectal post-op<\/strong> until oral possible<\/td><td><strong>Not specified in the source<\/strong><\/td><\/tr><tr><td><strong>Anaerobic infections \u2013 Prevention (Children)<\/strong><\/td><td>By weight<\/td><td>As for treatment (7.5 mg\/kg)<\/td><td>Every 8 hours<\/td><td>During or just after meals<\/td><td>As per surgical plan<\/td><td><strong>Not specified in the source<\/strong><\/td><\/tr><tr><td><strong>H. pylori-associated gastritis\/duodenal ulcer (Adults)<\/strong><\/td><td>Adults<\/td><td>200\u2013250 mg<\/td><td>4\u20135 times daily<\/td><td>As directed<\/td><td><strong>14 days<\/strong>, <strong>with other medicines<\/strong><\/td><td><strong>Not specified in the source<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Possible_side_effects\"><\/span>Possible side effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Like all medicines, BEMETRAZOLE can cause <a href=\"https:\/\/rxquora.com\/en\/alcophyllexuses-side-effects-precautions-and-more\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/alcophyllexuses-side-effects-precautions-and-more\/\">side effects<\/a>, although not everyone gets them. <strong>Stop the medicine and seek urgent medical help<\/strong> if you develop serious symptoms listed below.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Serious_%E2%80%94_seek_urgent_help\"><\/span>Serious \u2014 seek urgent help<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Stop BEMETRAZOLE and contact your doctor immediately or go to the nearest casualty if you notice:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Brain disease (encephalopathy):<\/strong> fever, stiff neck, headache, <strong>seeing or hearing things that are not there<\/strong>, problems speaking, problems using arms\/legs, or confusion.<\/li>\n\n\n\n<li><strong>Severe allergic reaction:<\/strong> swelling of <strong>hands, feet, ankles, face, lips, or throat<\/strong> causing difficulty <strong>swallowing or breathing<\/strong>, with <strong>itchy nettle-like rash (urticaria)<\/strong>.<\/li>\n\n\n\n<li><strong>Fainting<\/strong>.<\/li>\n\n\n\n<li><strong>Yellowing of the skin or eyes (jaundice)<\/strong> \u2014 may indicate <strong>liver problems<\/strong>.<\/li>\n\n\n\n<li><strong>Unexpected infections<\/strong>, <strong>mouth ulcers<\/strong>, <strong>bruising<\/strong>, <strong>bleeding gums<\/strong>, or <strong>severe tiredness<\/strong> \u2014 may indicate a <strong>blood problem<\/strong>.<\/li>\n\n\n\n<li><strong>Severe stomach pain<\/strong> that may also be felt in the back \u2014 may indicate <strong>pancreatitis<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">These events may require <strong>urgent medical attention or hospital care<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Common\"><\/span>Common <span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Gastro-intestinal disturbances:<\/strong> <strong>nausea<\/strong>, <strong>taste disorders<\/strong> (metallic or altered taste), <strong>vomiting<\/strong><\/li>\n\n\n\n<li><strong>Diarrhoea<\/strong><\/li>\n\n\n\n<li><strong>Dry mouth<\/strong><\/li>\n\n\n\n<li><strong>Furred tongue<\/strong><\/li>\n\n\n\n<li><strong>Oral mucositis<\/strong> (sore\/red mouth)<\/li>\n\n\n\n<li><strong>Stomatitis<\/strong> (mouth soreness, ulcers, or cold sores)<\/li>\n\n\n\n<li><strong>Headache<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Less_common\"><\/span>Less common <span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Mental problems<\/strong> such as <strong>confusion<\/strong> or <strong>hallucinations<\/strong><\/li>\n\n\n\n<li><strong>Vision problems<\/strong> such as <strong>blurred<\/strong> or <strong>double vision<\/strong><\/li>\n\n\n\n<li><strong>Weakness<\/strong><\/li>\n\n\n\n<li><strong><a href=\"https:\/\/rxquora.com\/en\/relislim-uses-side-effects-precautions-and-more\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/relislim-uses-side-effects-precautions-and-more\/\">Dizziness<\/a><\/strong><\/li>\n\n\n\n<li><strong>Drowsiness<\/strong><\/li>\n\n\n\n<li><strong>Skin rash<\/strong><\/li>\n\n\n\n<li><strong>Darkening of the urine<\/strong><\/li>\n\n\n\n<li><strong>Sleep problems<\/strong> (unable to sleep)<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Additional_side_effects\"><\/span>Additional side effects <span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Low white blood cell count<\/strong><\/li>\n\n\n\n<li><strong>Weight loss<\/strong><\/li>\n\n\n\n<li><strong>Numbness, tingling, pain, or weakness<\/strong> in arms or legs<\/li>\n\n\n\n<li><strong>Unpleasant taste<\/strong><\/li>\n\n\n\n<li><strong>Upset stomach, stomach pain, loss of appetite<\/strong><\/li>\n\n\n\n<li><strong>Fever<\/strong><\/li>\n\n\n\n<li><strong>Feeling depressed<\/strong><\/li>\n\n\n\n<li><strong>Eye pain (optic neuritis)<\/strong><\/li>\n\n\n\n<li><strong>Meningitis-like symptoms:<\/strong> fever, nausea, vomiting, headache, stiff neck, extreme sensitivity to bright light<\/li>\n\n\n\n<li><strong>Hearing impairment or hearing loss<\/strong><\/li>\n\n\n\n<li><strong>Ringing in the ears (tinnitus)<\/strong><\/li>\n\n\n\n<li><strong>Rash or skin discolouration<\/strong> that may <strong>recur in the same spot<\/strong> when the drug is taken again<\/li>\n\n\n\n<li><strong>Nasal congestion<\/strong><\/li>\n\n\n\n<li><strong>Skin rashes<\/strong><\/li>\n\n\n\n<li><strong>Joint pain<\/strong><\/li>\n\n\n\n<li><strong>Muscle pain<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>What to do about side effects<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Mild symptoms<\/strong> (like nausea or metallic taste) often improve as your body adjusts. Mention them at your next check-in.<\/li>\n\n\n\n<li><strong>Severe, persistent, or worrying symptoms<\/strong> (especially those under \u201cSerious\u201d) need <strong>urgent medical attention<\/strong>.<\/li>\n\n\n\n<li>You can report side effects to <strong>SAHPRA<\/strong> using the <strong>\u201c6.04 Adverse Drug Reaction Reporting Form\u201d<\/strong> found under SAHPRA\u2019s publications.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Note:<\/strong> Not all possible side effects are listed in the source. If your <strong>general health worsens<\/strong>, speak to your healthcare professional.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Storage_and_disposal\"><\/span>Storage and disposal<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Keep out of the reach of children.<\/strong><\/li>\n\n\n\n<li><strong>Store at or below 25 \u00b0C.<\/strong><\/li>\n\n\n\n<li>Keep in the <strong>original packaging<\/strong> to <strong>protect from light<\/strong>.<\/li>\n\n\n\n<li><strong>Do not use<\/strong> after the <strong>expiry date<\/strong> on the packaging.<\/li>\n\n\n\n<li><strong>Return all unused medicine to your pharmacist.<\/strong><\/li>\n\n\n\n<li><strong>Do not<\/strong> dispose of unused tablets in <strong>toilets, drains, or sewerage systems<\/strong>.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_the_medicine_contains\"><\/span>What the medicine contains<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Active ingredient:<\/strong><strong>Metronidazole<\/strong>\n<ul class=\"wp-block-list\">\n<li>BEMETRAZOLE <strong>200<\/strong>: each tablet contains <strong>metronidazole 200 mg<\/strong><\/li>\n\n\n\n<li>BEMETRAZOLE <strong>400<\/strong>: each tablet contains <strong>metronidazole 400 mg<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Other ingredients (excipients):<\/strong><br><strong>Lactose monohydrate 200 mesh<\/strong>, <strong>magnesium stearate<\/strong>, <strong>maize starch<\/strong>, <strong>pregelatinised starch<\/strong>, <strong>purified talc<\/strong>.<\/li>\n\n\n\n<li><strong>Lactose content per tablet:<\/strong>\n<ul class=\"wp-block-list\">\n<li>200 mg tablet: <strong>lactose 100 mg<\/strong><\/li>\n\n\n\n<li>400 mg tablet: <strong>lactose 80 mg<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Note:<\/strong> If you have a known lactose intolerance, consult your doctor before use.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pack_information_and_appearance\"><\/span>Pack information and appearance<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Appearance:<\/strong> <strong>Round<\/strong>, <strong>biconvex<\/strong>, <strong>scored<\/strong> tablets (both strengths).<\/li>\n\n\n\n<li><strong>Packs \u2014 BEMETRAZOLE 200 mg:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>Securitainers<\/strong> of <strong>21\u2019s, 100\u2019s, or 500\u2019s<\/strong>; <strong>patient-ready packs<\/strong> of different sizes.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Packs \u2014 BEMETRAZOLE 400 mg:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>Securitainers<\/strong> of <strong>10\u2019s, 100\u2019s, or 500\u2019s<\/strong>; <strong>500\u2019s in HDPE containers<\/strong>; <strong>patient-ready packs<\/strong> of different sizes.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Holder of Certificate of Registration:<\/strong> Ranbaxy Pharmaceuticals (Pty) Ltd.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FAQs\"><\/span>FAQs <span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1) Can I drink alcohol while taking BEMETRAZOLE?<\/strong><br><strong>No.<\/strong> Do not drink alcohol during treatment and for <strong>1\u20133 days after<\/strong> finishing. Alcohol may cause <strong>nausea, vomiting, stomach pains, flushing, palpitations, and headache<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>2) Is it safe to drive or use machines?<\/strong><br><strong>Not if you are affected.<\/strong> BEMETRAZOLE may cause <strong>sleepiness, dizziness, confusion, hallucinations, fits<\/strong>, or <strong>blurred\/double vision<\/strong>. If these occur, <strong>do not drive or operate machines<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>3) I forgot a dose. What should I do?<\/strong><br>Take it <strong>as soon as you remember<\/strong>. If it is almost time for the next dose, <strong>skip the missed dose<\/strong>. <strong>Do not<\/strong> take a <strong>double dose<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>4) I\u2019m on warfarin. Can I take BEMETRAZOLE?<\/strong><br>Tell your doctor. Metronidazole can <strong>intensify warfarin\u2019s effect<\/strong> and may lead to <strong>uncontrolled bleeding<\/strong>. Close monitoring may be needed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>5) I take lithium. Is there a problem?<\/strong><br>Tell your doctor. Metronidazole may <strong>increase lithium levels<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>6) I have epilepsy and use phenytoin or phenobarbital.<\/strong><br>These medicines may <strong>reduce the effectiveness<\/strong> of metronidazole. Your doctor will advise you.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>7) I\u2019m on disulfiram for alcohol dependence.<\/strong><br>Do <strong>not<\/strong> combine with BEMETRAZOLE as it can cause <strong>acute confusion<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>8) I have Cockayne syndrome. Can I use this medicine?<\/strong><br>Use only under close medical supervision. There is a risk of <strong>severe liver toxicity\/acute liver failure<\/strong>; <strong>stop the medicine and seek medical advice immediately<\/strong> if liver injury symptoms occur. <strong>Liver tests<\/strong> should be monitored during treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>9) I have lactose intolerance.<\/strong><br>BEMETRAZOLE contains <strong>lactose<\/strong> (100 mg per 200 mg tablet; 80 mg per 400 mg tablet). <strong>Consult your doctor before use.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>10) How long must I take it?<\/strong><br>Your doctor decides based on your infection. For anaerobic infections, <strong>7 days or longer<\/strong> may be required. For <strong>H. pylori<\/strong> regimens, <strong>14 days<\/strong> together with <strong>other medicines<\/strong> are used.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>BEMETRAZOLE (metronidazole) is an antibiotic and antiprotozoal medicine used to treat certain bacterial infections and to help prevent infection after surgery. It is available as tablets in two strengths: 200 mg and 400 mg of metronidazole. In South Africa, it is a Schedule 4 (S4) medicine, which means it is available on prescription only and &#8230; <a title=\"BEMETRAZOLE: Uses,Dose,Side-Effects,Precautions\" class=\"read-more\" href=\"https:\/\/rxquora.com\/en\/bemetrazole-uses-dose-side-effects-precautions\/\" aria-label=\"Read more about BEMETRAZOLE: Uses,Dose,Side-Effects,Precautions\">Read more<\/a><\/p>\n","protected":false},"author":3,"featured_media":2191,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[],"class_list":["post-2138","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicines"],"_links":{"self":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/posts\/2138","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/comments?post=2138"}],"version-history":[{"count":0,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/posts\/2138\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/media\/2191"}],"wp:attachment":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/media?parent=2138"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/categories?post=2138"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/tags?post=2138"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}