{"id":2144,"date":"2025-09-19T17:53:52","date_gmt":"2025-09-19T15:53:52","guid":{"rendered":"https:\/\/rxquora.com\/en\/?p=2144"},"modified":"2025-09-21T11:39:55","modified_gmt":"2025-09-21T09:39:55","slug":"omez-uses-dose-side-effects-precautions","status":"publish","type":"post","link":"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/","title":{"rendered":"OMEZ :Uses, Dose, Side-Effects, Precautions"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>OMEZ<\/strong> is a prescription medicine that reduces the amount of acid made in your stomach. It contains <strong>omeprazole<\/strong>, a proton pump inhibitor (PPI). Lowering stomach acid helps ulcers to heal, eases heartburn caused by gastro-oesophageal reflux disease (GORD), and treats conditions where the stomach produces too much acid. <\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_it_is_and_what_it_is_used_for\"><\/span>What it is and what it is used for<span class=\"ez-toc-section-end\"><\/span><\/h2><div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#What_it_is_and_what_it_is_used_for\" >What it is and what it is used for<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#How_it_works\" >How it works<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#Who_should_NOT_use_this_medicine\" >Who should NOT use this medicine<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#Warnings_and_precautions_Read_before_use\" >Warnings and precautions (Read before use)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#Pregnancy_planning_pregnancy_and_breastfeeding\" >Pregnancy, planning pregnancy, and breastfeeding<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#Interactions\" >Interactions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#How_to_take_Step-by-step\" >How to take (Step-by-step)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#Dosing_table\" >Dosing table<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#Adults_follow_medical_advice_doses_are_once_daily_unless_stated\" >Adults (follow medical advice; doses are once daily unless stated)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#Children_%E2%89%A51_year_%E2%80%94_severe_ulcerative_reflux_oesophagitis_resistant_to_prior_treatment\" >Children (\u22651 year) \u2014 severe ulcerative reflux oesophagitis resistant to prior treatment<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#Possible_side_effects\" >Possible side effects<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#Common_reported_as_%E2%80%9CFrequent%E2%80%9D\" >Common (reported as \u201cFrequent\u201d)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#Less_common_reported_as_%E2%80%9CLess_frequent%E2%80%9D\" >Less common (reported as \u201cLess frequent\u201d)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#Frequency_not_known_listed_in_the_insert_without_a_set_frequency\" >Frequency not known (listed in the insert without a set frequency)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#Serious%E2%80%94seek_urgent_help\" >Serious\u2014seek urgent help<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#Storage_and_disposal\" >Storage and disposal<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#What_the_medicine_contains\" >What the medicine contains<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#Pack_information_and_appearance\" >Pack information and appearance<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/#FAQs\" >FAQs<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n\n<p class=\"wp-block-paragraph\"><strong>What it is<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>OMEZ (omeprazole)<\/strong> is a <strong>proton pump inhibitor<\/strong>. PPIs switch off the acid \u201cpumps\u201d in the stomach lining to reduce acid production.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>What it is used for (adults)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Duodenal ulcer:<\/strong> treatment and <strong>prevention of relapse<\/strong>.<\/li>\n\n\n\n<li><strong>Gastric ulcer<\/strong> and <strong>reflux oesophagitis<\/strong> (inflammation of the food pipe from acid).<\/li>\n\n\n\n<li><strong>Long-term management<\/strong> of reflux oesophagitis.<\/li>\n\n\n\n<li><strong>Zollinger-Ellison Syndrome<\/strong> (a condition causing very high acid output).<\/li>\n\n\n\n<li><strong>Symptomatic relief of heartburn<\/strong> in patients with <strong>GORD<\/strong> and <strong>short-term relief of functional dyspepsia<\/strong>.<\/li>\n\n\n\n<li><strong>Helicobacter pylori-positive duodenal ulcers<\/strong> as part of an <strong>eradication programme<\/strong> with appropriate antibiotics.<\/li>\n\n\n\n<li><strong>NSAID-associated gastric and\/or duodenal ulcer\/erosions:<\/strong> treatment.<\/li>\n\n\n\n<li><strong>Prevention<\/strong> of NSAID-associated gastric\/duodenal ulcer\/erosions and reduction of relapse risk in patients on NSAIDs.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>What it is used for (children)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Short-term (up to 3 months)<\/strong> treatment of <strong>severe ulcerative reflux oesophagitis<\/strong> in children <strong>from 1 year of age<\/strong>, when resistant to previous medical treatment.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_it_works\"><\/span>How it works <span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Your stomach has microscopic acid pumps (called the <strong>H\u207a\/K\u207a-ATPase<\/strong>). OMEZ <strong>blocks these pumps<\/strong>, so less acid is released into the stomach. With less acid, ulcers can heal and reflux symptoms (like burning behind the breastbone) ease. OMEZ blocks both <strong>day-to-day (basal)<\/strong> acid production and <strong>stimulated<\/strong> acid secretion (for example, after a meal). It does <strong>not<\/strong> block the receptors for acetylcholine, histamine, or gastrin; it acts <strong>after<\/strong> these signals by turning off the final step of acid production.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Who_should_NOT_use_this_medicine\"><\/span>Who should NOT use this medicine<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Do not use OMEZ if:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>You are <strong>allergic<\/strong> to <strong>omeprazole<\/strong> or any of the capsule ingredients.<\/li>\n\n\n\n<li><strong>You are pregnant or breastfeeding.<\/strong> Safety in pregnancy and lactation has <strong>not been established<\/strong>.<\/li>\n\n\n\n<li>You take <strong>nelfinavir<\/strong> (an antiretroviral medicine).<\/li>\n\n\n\n<li>You are taking <strong>atazanavir<\/strong> \u2013 co-administration is <strong>not recommended<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Speak to your doctor urgently before starting if you have any \u201calarm\u201d symptoms:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Unintentional <strong>weight loss<\/strong>.<\/li>\n\n\n\n<li><strong>Recurrent vomiting<\/strong>.<\/li>\n\n\n\n<li><strong>Difficulty swallowing<\/strong> (dysphagia).<\/li>\n\n\n\n<li><strong>Vomiting blood<\/strong> (haematemesis) or <strong>black stools<\/strong> (melaena).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">These may indicate a more serious condition; treatment with OMEZ could mask symptoms and <strong>delay diagnosis<\/strong>, so cancer must be <strong>excluded<\/strong> in these cases.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Warnings_and_precautions_Read_before_use\"><\/span>Warnings and precautions (Read before use)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Liver or kidney issues:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>Hepatic impairment<\/strong> can increase omeprazole levels; a <strong>lower daily dose (10\u201320 mg)<\/strong> is generally sufficient.<\/li>\n\n\n\n<li>The <strong>long-term safety<\/strong> of OMEZ in <strong>renal and\/or hepatic impairment<\/strong> has <strong>not been established<\/strong>.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Children:<\/strong> Experience is <strong>limited<\/strong>. Some children with chronic conditions may need long-term therapy, but this is <strong>not recommended<\/strong>.<\/li>\n\n\n\n<li><strong>Antiretrovirals:<\/strong> <strong>Do not<\/strong> use with <strong>nelfinavir<\/strong>. <strong>Atazanavir<\/strong> with PPIs is <strong>not recommended<\/strong>; if unavoidable, close monitoring is required and <strong>omeprazole 20 mg should not be exceeded<\/strong>.<\/li>\n\n\n\n<li><strong>Vitamin B12:<\/strong> Long-term acid reduction can reduce <strong>vitamin B12<\/strong> absorption (due to low stomach acid). Consider this in patients at risk of deficiency.<\/li>\n\n\n\n<li><strong>Clopidogrel:<\/strong> OMEZ <strong>inhibits CYP2C19<\/strong> and can <strong>reduce<\/strong> the activation of clopidogrel. <strong>Concomitant use should be discouraged<\/strong>.<\/li>\n\n\n\n<li><strong>Bone fractures:<\/strong> High doses and <strong>long-term use (&gt;1 year)<\/strong> may <strong>slightly increase<\/strong> hip, wrist, and spine fracture risk (10\u201340% increase seen in observational studies), especially in elderly people or those with other risks. Ensure <strong>adequate calcium and vitamin D<\/strong> as per clinical guidance.<\/li>\n\n\n\n<li><strong>Low magnesium (hypomagnesaemia):<\/strong> After <strong>\u22653 months<\/strong> (often a year) of PPI use, severe low magnesium can occur (fatigue, muscle cramps\/tetany, confusion, seizures, dizziness, abnormal heart rhythms). This usually improves after <strong>stopping OMEZ<\/strong> and <strong>replacing magnesium<\/strong>. If long-term therapy is expected, or if taken with <strong>digoxin<\/strong> or <strong>diuretics<\/strong>, your healthcare provider may <strong>check magnesium levels<\/strong> before and during treatment.<\/li>\n\n\n\n<li><strong>Subacute cutaneous lupus erythematosus (SCLE):<\/strong> Very rare. If you develop <strong>ring-shaped or scaly skin lesions<\/strong> on sun-exposed areas, with or without <strong>joint pain<\/strong>, <strong>seek medical help<\/strong> and your doctor may stop OMEZ.<\/li>\n\n\n\n<li><strong>Lab test interference:<\/strong> OMEZ can <strong>increase Chromogranin A (CgA)<\/strong>, which may interfere with tests for <strong>neuroendocrine tumours<\/strong>. Stop OMEZ for <strong>at least 5 days<\/strong> before CgA testing. If results are still high, <strong>repeat 14 days<\/strong> after stopping.<\/li>\n\n\n\n<li><strong>Infections and gut changes:<\/strong> Long-term acid suppression may increase the number of normal stomach bacteria and is associated with a <strong>higher risk of gastrointestinal infections<\/strong> (e.g., <strong>Salmonella<\/strong>, <strong>Campylobacter<\/strong>, <strong>Clostridium difficile<\/strong>).<\/li>\n\n\n\n<li><strong>Clostridium difficile-associated diarrhoea (CDAD):<\/strong> PPIs may increase risk, especially in hospitalised patients. Consider this diagnosis if <strong>diarrhoea persists<\/strong>.<\/li>\n\n\n\n<li><strong>Kidney inflammation (Acute tubulointerstitial nephritis):<\/strong> Can occur at any time during therapy and may lead to acute kidney injury. Symptoms range from allergic-type reactions to non-specific signs of reduced kidney function (malaise, nausea, poor appetite). <strong>Stop OMEZ and seek medical evaluation<\/strong> if suspected.<\/li>\n\n\n\n<li><strong>Use the lowest effective dose for the shortest time<\/strong> needed for your condition.<\/li>\n\n\n\n<li><strong>Contains mannitol:<\/strong> Rarely causes hypersensitivity and may have a <strong>laxative effect<\/strong>.<\/li>\n\n\n\n<li><strong>Driving and machinery:<\/strong> OMEZ may cause <strong>drowsiness<\/strong> or <strong>reduced concentration<\/strong>, which can be <strong>worsened by alcohol<\/strong> or other sedatives. Especially when starting therapy, avoid driving or operating machinery if affected.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pregnancy_planning_pregnancy_and_breastfeeding\"><\/span>Pregnancy, planning pregnancy, and breastfeeding<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Safety in pregnancy and lactation has not been established.Speak to your doctor or pharmacist before use.<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Interactions\"><\/span>Interactions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Important:<\/strong> Always tell your doctor and pharmacist about all medicines you take.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Clopidogrel:<\/strong> OMEZ <strong>reduces<\/strong> clopidogrel\u2019s activation via <strong>CYP2C19<\/strong>. <strong>Concomitant use should be discouraged.<\/strong><\/li>\n\n\n\n<li><strong>CYP-metabolised medicines:<\/strong> OMEZ is metabolised by the liver <strong>(CYP system)<\/strong> and can <strong>affect<\/strong> other medicines processed by these enzymes.\n<ul class=\"wp-block-list\">\n<li><strong>Diazepam, warfarin, phenytoin:<\/strong> Elimination may be <strong>prolonged<\/strong>. <strong>INR<\/strong> (for warfarin) and <strong>phenytoin levels<\/strong> should be <strong>monitored<\/strong>; <strong>dose adjustments<\/strong> may be needed.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Digoxin:<\/strong> OMEZ 20 mg daily can <strong>increase digoxin bioavailability by ~10%<\/strong>. Toxicity is rare but use caution, especially at <strong>high OMEZ doses<\/strong> in <strong>elderly<\/strong> patients; consider <strong>therapeutic drug monitoring<\/strong>.<\/li>\n\n\n\n<li><strong>Antiretrovirals:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>Nelfinavir:<\/strong> <strong>Contraindicated<\/strong> with OMEZ (significant reduction in nelfinavir and its active metabolite).<\/li>\n\n\n\n<li><strong>Atazanavir:<\/strong> <strong>Not recommended<\/strong> with OMEZ (markedly reduced exposure). Increasing atazanavir dose may <strong>not<\/strong> overcome the effect; avoid the combination.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Tacrolimus:<\/strong> Serum levels may <strong>increase<\/strong>. <strong>Monitor tacrolimus concentrations<\/strong> and <strong>renal function<\/strong>; adjust dose if required.<\/li>\n\n\n\n<li><strong>Methotrexate:<\/strong> Levels can <strong>increase<\/strong> when given with OMEZ. With <strong>high-dose methotrexate<\/strong>, consider <strong>temporarily stopping<\/strong> OMEZ.<\/li>\n\n\n\n<li><strong>Antifungals\/other medicines affected by gastric pH:<\/strong>\n<ul class=\"wp-block-list\">\n<li><strong>Posaconazole and erlotinib:<\/strong> Absorption <strong>significantly reduced<\/strong>; <strong>avoid concomitant use<\/strong>.<\/li>\n\n\n\n<li><strong>Ketoconazole and itraconazole:<\/strong> Absorption <strong>reduced<\/strong>; efficacy may be impaired.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Vitamin B12:<\/strong> Long-term acid suppression can reduce <strong>cyanocobalamin<\/strong> absorption.<\/li>\n\n\n\n<li><strong>Laboratory tests:<\/strong> OMEZ can <strong>raise CgA<\/strong>, potentially <strong>confusing<\/strong> tests for certain tumours; follow the <strong>5-day stop<\/strong> guidance above.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_to_take_Step-by-step\"><\/span>How to take (Step-by-step)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>General guidance<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Timing:<\/strong> Take OMEZ <strong>in the morning<\/strong>.<\/li>\n\n\n\n<li><strong>How to swallow:<\/strong> <strong>Swallow the capsule whole<\/strong> with <strong>half a glass of liquid<\/strong>. <strong>Do not crush or chew<\/strong> the capsule or pellets.<\/li>\n\n\n\n<li><strong>With food:<\/strong> Food <strong>does not<\/strong> affect omeprazole\u2019s bioavailability (no specific instruction to take with or without food is required in the source).<\/li>\n\n\n\n<li><strong>Do not change your dose<\/strong> without medical advice, especially in long-term treatment.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Adult dosing (follow your doctor\u2019s instructions):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Duodenal ulcer:<\/strong> <strong>20 mg once daily for 2\u20134 weeks.<\/strong> Some patients who did not respond to other treatments may need <strong>40 mg once daily<\/strong>.<\/li>\n\n\n\n<li><strong>Prevention of duodenal ulcer relapse:<\/strong> <strong>10 mg once daily.<\/strong> If needed, increase to <strong>20\u201340 mg once daily<\/strong>.<\/li>\n\n\n\n<li><strong><em>H. pylori<\/em>-positive duodenal ulcer:<\/strong> As above <strong>plus appropriate antibiotics<\/strong> as part of an eradication programme.<\/li>\n\n\n\n<li><strong><a href=\"https:\/\/rxquora.com\/en\/famucaps-capsules-uses-dosage-side-effects-warnings\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/famucaps-capsules-uses-dosage-side-effects-warnings\/\">Gastric ulcer<\/a> and reflux oesophagitis:<\/strong> <strong>20 mg once daily for 4\u20138 weeks.<\/strong> If refractory to other regimens, <strong>40 mg once daily<\/strong> may be effective.<\/li>\n\n\n\n<li><strong>Long-term management of reflux oesophagitis:<\/strong> <strong>20 mg once daily<\/strong>; if necessary, up to <strong>40 mg once daily<\/strong>. In severe or symptomatic recurrent oesophagitis, continue <strong>20 mg once daily<\/strong>.<\/li>\n\n\n\n<li><strong>NSAID-associated gastric\/duodenal lesions (with or without ongoing NSAIDs):<\/strong> <strong>20 mg once daily.<\/strong> Most heal within <strong>4 weeks<\/strong>; if not fully healed, continue for another <strong>4 weeks<\/strong>.<\/li>\n\n\n\n<li><strong>Prevention of NSAID-associated lesions and dyspeptic symptoms:<\/strong> <strong>20 mg once daily.<\/strong><\/li>\n\n\n\n<li><strong>Symptomatic GORD:<\/strong> <strong>20 mg once daily.<\/strong> Some patients may respond to <strong>10 mg daily<\/strong>; tailor the dose individually. If symptoms are not controlled after <strong>2 weeks at 20 mg daily<\/strong>, further investigation is recommended.<\/li>\n\n\n\n<li><strong>Zollinger-Ellison Syndrome:<\/strong> <strong>60 mg once daily<\/strong>, then adjust <strong>individually<\/strong> as needed. For <strong>&gt;80 mg\/day<\/strong>, split into <strong>two doses<\/strong> (morning and evening).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Paediatric dosing (children \u22651 year) \u2014 severe ulcerative reflux oesophagitis resistant to prior treatment (short-term up to 3 months):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>10\u201320 kg:<\/strong> <strong>10 mg once daily<\/strong>; if needed, increase to <strong>20 mg once daily<\/strong>.<\/li>\n\n\n\n<li><strong>&gt;20 kg:<\/strong> <strong>20 mg once daily<\/strong>; if needed, increase to <strong>40 mg once daily<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Special populations<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Elderly:<\/strong> No routine <strong>dose reduction<\/strong> required.<\/li>\n\n\n\n<li><strong>Renal impairment:<\/strong> No <strong>dose reduction<\/strong> required.<\/li>\n\n\n\n<li><strong>Hepatic impairment:<\/strong> <strong>Bioavailability and half-life are increased<\/strong>; in general, <strong>10\u201320 mg daily<\/strong> is <strong>sufficient<\/strong>.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Missed dose and overdose<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Missed dose:<\/strong> <strong>Not specified in the source.<\/strong> Speak to your pharmacist or doctor for personalised advice.<\/li>\n\n\n\n<li><strong>Overdose:<\/strong> Reported symptoms include <strong>blurred vision, confusion, sweating, flushing, headache, malaise, nausea, tachycardia<\/strong>. There is <strong>no specific antidote<\/strong>; treatment is <strong>supportive<\/strong>. Omeprazole is <strong>not readily dialysable<\/strong>. If overdose is suspected, <strong>seek medical attention<\/strong>.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dosing_table\"><\/span>Dosing table<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Adults_follow_medical_advice_doses_are_once_daily_unless_stated\"><\/span>Adults (follow medical advice; doses are once daily unless stated)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Indication<\/th><th>Usual dose<\/th><th>Duration<\/th><th>Notes<\/th><\/tr><\/thead><tbody><tr><td>Duodenal ulcer<\/td><td>20 mg<\/td><td>2\u20134 weeks<\/td><td>Refractory to other regimens: 40 mg<\/td><\/tr><tr><td>Prevention of duodenal ulcer relapse<\/td><td>10 mg<\/td><td>Ongoing<\/td><td>May increase to 20\u201340 mg if needed<\/td><\/tr><tr><td><em>H. pylori<\/em>-positive duodenal ulcer<\/td><td>As above<\/td><td>Per regimen<\/td><td>Use <strong>with appropriate antibiotics<\/strong> as eradication therapy<\/td><\/tr><tr><td>Gastric ulcer<\/td><td>20 mg<\/td><td>4\u20138 weeks<\/td><td>Refractory: 40 mg<\/td><\/tr><tr><td>Reflux oesophagitis (acute)<\/td><td>20 mg<\/td><td>4\u20138 weeks<\/td><td>Refractory: 40 mg<\/td><\/tr><tr><td>Reflux oesophagitis (long-term management)<\/td><td>20 mg<\/td><td>Ongoing<\/td><td>If necessary, increase up to 40 mg<\/td><\/tr><tr><td>Severe\/recurrent symptomatic reflux oesophagitis<\/td><td>20 mg<\/td><td>Ongoing<\/td><td>Continue at 20 mg once daily<\/td><\/tr><tr><td>NSAID-associated gastric\/duodenal lesions (treatment)<\/td><td>20 mg<\/td><td>Usually 4 weeks<\/td><td>If not healed, an additional 4 weeks<\/td><\/tr><tr><td>Prevention of NSAID-associated lesions\/dyspeptic symptoms<\/td><td>20 mg<\/td><td>Ongoing<\/td><td>While on NSAIDs<\/td><\/tr><tr><td>Symptomatic GORD<\/td><td>20 mg<\/td><td>Review after 2 weeks<\/td><td>Some respond to 10 mg; investigate if no control after 2 weeks at 20 mg<\/td><\/tr><tr><td>Zollinger-Ellison Syndrome<\/td><td>60 mg (initial)<\/td><td>Individualised<\/td><td>If <strong>&gt;80 mg\/day<\/strong>, <strong>divide<\/strong> into two daily doses<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Children_%E2%89%A51_year_%E2%80%94_severe_ulcerative_reflux_oesophagitis_resistant_to_prior_treatment\"><\/span>Children (\u22651 year) \u2014 severe ulcerative reflux oesophagitis resistant to prior treatment<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Weight<\/th><th>Starting dose<\/th><th>If needed<\/th><\/tr><\/thead><tbody><tr><td>10\u201320 kg<\/td><td>10 mg once daily<\/td><td>Increase to 20 mg once daily<\/td><\/tr><tr><td>&gt;20 kg<\/td><td>20 mg once daily<\/td><td>Increase to 40 mg once daily<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Note:<\/strong> Paediatric use is <strong>short-term (up to 3 months)<\/strong>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Possible_side_effects\"><\/span>Possible side effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Below is a consolidated list based on the package insert. If any <a href=\"https:\/\/rxquora.com\/en\/lupus-symptoms-types-causes-and-treatment\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/lupus-symptoms-types-causes-and-treatment\/\">side effect<\/a> worries you, <strong>speak to your doctor or pharmacist<\/strong>. <strong>Seek urgent help<\/strong> for <a href=\"https:\/\/rxquora.com\/en\/lorien-uses-dose-side-effects-precautions\/\" data-type=\"link\" data-id=\"https:\/\/rxquora.com\/en\/lorien-uses-dose-side-effects-precautions\/\">serious reactions<\/a> (see the final subsection).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Common_reported_as_%E2%80%9CFrequent%E2%80%9D\"><\/span>Common (reported as \u201cFrequent\u201d)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Headache<\/strong> (in some cases severe enough to stop treatment).<\/li>\n\n\n\n<li><strong>Diarrhoea<\/strong> (occasionally severe enough to stop treatment).<\/li>\n\n\n\n<li><strong>Constipation<\/strong>.<\/li>\n\n\n\n<li><strong>Abdominal pain\/colic<\/strong>.<\/li>\n\n\n\n<li><strong>Nausea or vomiting<\/strong>.<\/li>\n\n\n\n<li><strong>Flatulence<\/strong>.<\/li>\n\n\n\n<li><strong>Gastric glandular cysts<\/strong> and <strong>fundic gland polyps (benign)<\/strong>.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Less_common_reported_as_%E2%80%9CLess_frequent%E2%80%9D\"><\/span>Less common (reported as \u201cLess frequent\u201d)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Blood\/lymph:<\/strong> Low white cells (<strong>leucopenia<\/strong>), low platelets (<strong>thrombocytopenia<\/strong>), <strong>agranulocytosis<\/strong>, <strong>pancytopenia<\/strong>.<\/li>\n\n\n\n<li><strong>Endocrine:<\/strong> <strong>Gynaecomastia<\/strong>.<\/li>\n\n\n\n<li><strong>Metabolism:<\/strong> <strong>Hyponatraemia<\/strong>, <strong>hypomagnesaemia<\/strong>.<\/li>\n\n\n\n<li><strong>Psychiatric:<\/strong> Reversible <strong>confusion<\/strong>, <strong>agitation<\/strong>, <strong>aggression<\/strong>, <strong>depression<\/strong>, <strong>hallucinations<\/strong> (mostly in severely ill patients).<\/li>\n\n\n\n<li><strong>Nervous system:<\/strong> <strong>Dizziness<\/strong>, <strong>drowsiness (somnolence)<\/strong>, <strong>insomnia<\/strong>, <strong>paraesthesias<\/strong>.<\/li>\n\n\n\n<li><strong>Eyes:<\/strong> <strong>Blurred vision<\/strong>.<\/li>\n\n\n\n<li><strong>Vascular:<\/strong> <strong>Peripheral oedema<\/strong>.<\/li>\n\n\n\n<li><strong>Respiratory:<\/strong> <strong>Bronchospasm<\/strong>.<\/li>\n\n\n\n<li><strong>Gastrointestinal:<\/strong> <strong>Dry mouth<\/strong>, <strong>stomatitis<\/strong>, <strong>oesophageal candidiasis<\/strong>, <strong>taste disturbances<\/strong>.<\/li>\n\n\n\n<li><strong>Liver:<\/strong> <strong>Raised liver enzymes<\/strong>, <strong>hepatitis<\/strong> (with or without <strong>jaundice<\/strong>), <strong>hepatic encephalopathy<\/strong>.<\/li>\n\n\n\n<li><strong>Skin:<\/strong> <strong>Rash<\/strong>, <strong>urticaria<\/strong>, <strong>itching (pruritus)<\/strong>, <strong>photosensitivity<\/strong>, <strong>bullous eruptions<\/strong>, <strong>toxic epidermal necrolysis<\/strong>, <strong>Stevens-Johnson syndrome<\/strong>, <strong>alopecia<\/strong>, <strong>erythema multiforme<\/strong>.<\/li>\n\n\n\n<li><strong>Musculoskeletal:<\/strong> <strong>Weakness (asthenia)<\/strong>, <strong>joint pain (arthralgia)<\/strong>, <strong>muscle pain (myalgia)<\/strong>, <strong>bone fractures<\/strong>.<\/li>\n\n\n\n<li><strong>Renal\/urinary:<\/strong> <strong>Interstitial nephritis<\/strong>.<\/li>\n\n\n\n<li><strong>Immune:<\/strong> <strong>Hypersensitivity reactions<\/strong> (fever, angioedema, bronchospasm, interstitial nephritis).<\/li>\n\n\n\n<li><strong>General:<\/strong> <strong>Malaise<\/strong>.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Frequency_not_known_listed_in_the_insert_without_a_set_frequency\"><\/span>Frequency not known (listed in the insert without a set frequency)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Clostridium difficile-associated diarrhoea (CDAD)<\/strong>.<\/li>\n\n\n\n<li><strong>Microscopic colitis<\/strong>.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Serious%E2%80%94seek_urgent_help\"><\/span>Serious\u2014seek urgent help<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Stop OMEZ and <strong>get medical attention immediately<\/strong> if you notice:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Allergic reactions<\/strong> such as face, tongue, or throat swelling (<strong>angioedema<\/strong>), wheezing\/shortness of breath (<strong>bronchospasm<\/strong>), widespread rash or blistering (<strong>Stevens-Johnson syndrome<\/strong>, <strong>toxic epidermal necrolysis<\/strong>), fever.<\/li>\n\n\n\n<li><strong>Severe persistent diarrhoea<\/strong>, especially if watery or with blood (possible <strong>C. difficile<\/strong> infection).<\/li>\n\n\n\n<li><strong>Yellowing of the skin or eyes<\/strong>, very dark urine, or confusion (possible <strong>liver problems<\/strong>, including <strong>hepatic encephalopathy<\/strong>).<\/li>\n\n\n\n<li><strong>Unexplained bruising\/bleeding<\/strong>, recurrent infections, or extreme tiredness (possible <strong>blood cell disorders<\/strong>).<\/li>\n\n\n\n<li><strong>Sudden reduction in urine<\/strong>, swelling in legs, or flank pain (possible <strong>kidney inflammation<\/strong>).<\/li>\n\n\n\n<li><strong>Severe low magnesium<\/strong> symptoms: muscle cramps\/twitches, seizures, confusion, or heart rhythm changes.<\/li>\n\n\n\n<li><strong>Ring-shaped or scaly skin lesions<\/strong>, particularly on sun-exposed skin, with joint pain (possible <strong>SCLE<\/strong>).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>What to do:<\/strong> Stop the medicine and <strong>contact your doctor or the nearest emergency unit<\/strong>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Storage_and_disposal\"><\/span>Storage and disposal<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Store at or below 25 \u00b0C.<\/strong><\/li>\n\n\n\n<li><strong>Protect from light and moisture.<\/strong><\/li>\n\n\n\n<li>Keep <strong>blisters in the outer carton<\/strong> until use.<\/li>\n\n\n\n<li><strong>Keep containers tightly closed.<\/strong><\/li>\n\n\n\n<li><strong>Shelf life:<\/strong> <strong>3 years<\/strong>.<\/li>\n\n\n\n<li>Keep out of the <strong>sight and reach of children<\/strong>.<\/li>\n\n\n\n<li><strong>Disposal:<\/strong> Any unused product or waste should be discarded <strong>according to local requirements<\/strong> (ask your pharmacist).<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_the_medicine_contains\"><\/span>What the medicine contains<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Active ingredient:<\/strong> <strong>Omeprazole<\/strong> 10 mg, 20 mg, or 40 mg per capsule.<\/li>\n\n\n\n<li><strong>Excipients include:<\/strong> crospovidone, hydroxypropyl methyl cellulose, magnesium stearate, <strong>mannitol<\/strong> (sugar; may have a laxative effect and rarely cause hypersensitivity), meglumine, methacrylic acid copolymer (Type C), poloxamer, povidone, triethyl citrate.<\/li>\n\n\n\n<li><strong>Capsule shell components:<\/strong> gelatin, titanium dioxide, and permitted colourants (including D&amp;C red #28, FD&amp;C blue #1, FD&amp;C red #40, FD&amp;C yellow #6; yellow iron oxide in 10 mg and 40 mg; black iron oxide in 20 mg).<\/li>\n\n\n\n<li><strong>Printing ink:<\/strong> mixture of iron oxides and approved lakes with pharmaceutical glaze and propylene glycol.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">If you have known allergies to colourants or excipients, <strong>review this list with your pharmacist<\/strong>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Pack_information_and_appearance\"><\/span>Pack information and appearance<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Pharmaceutical form:<\/strong> <strong>Capsule<\/strong> containing off-white to pale yellow <strong>enteric-coated pellets<\/strong>.<\/li>\n\n\n\n<li><strong>OMEZ 10 mg:<\/strong> Capsule with <strong>opaque lavender cap<\/strong> and <strong>opaque yellow body<\/strong>; imprinted \u201c<strong>Omeprazole 10 mg<\/strong>\u201d on cap and \u201c<strong>R157<\/strong>\u201d on body (black ink).<\/li>\n\n\n\n<li><strong>OMEZ 20 mg:<\/strong> Capsule with <strong>opaque lavender cap<\/strong> and <strong>opaque iron grey body<\/strong>; imprinted \u201c<strong>Omeprazole 20 mg<\/strong>\u201d on cap and \u201c<strong>R158<\/strong>\u201d on body.<\/li>\n\n\n\n<li><strong>OMEZ 40 mg:<\/strong> Capsule with <strong>opaque yellow cap<\/strong> and <strong>opaque purple body<\/strong>; imprinted \u201c<strong>Omeprazole 40 mg<\/strong>\u201d on cap and \u201c<strong>R159<\/strong>\u201d on body.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Pack sizes<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>OMEZ 10 mg:<\/strong> Blisters <strong>30 or 100<\/strong>; white HDPE bottles <strong>30 or 100<\/strong>.<\/li>\n\n\n\n<li><strong>OMEZ 20 mg:<\/strong> Blisters <strong>14, 30 or 100<\/strong>; white HDPE bottles <strong>14, 30, 100 or 1000<\/strong>.<\/li>\n\n\n\n<li><strong>OMEZ 40 mg:<\/strong> Blisters <strong>14, 28, 30 or 100<\/strong>; white HDPE bottles <strong>30, 100 or 500<\/strong>.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FAQs\"><\/span>FAQs <span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Can I take OMEZ during pregnancy or while breastfeeding?<\/strong><br><strong>Safety has not been established.<\/strong> Speak to your doctor before using OMEZ if you are pregnant, planning a pregnancy, or breastfeeding.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>When should I take OMEZ\u2014morning or evening?<\/strong><br>OMEZ is <strong>recommended in the morning<\/strong>. <strong>Swallow whole<\/strong> with half a glass of liquid.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Can I open, crush, or chew the capsules?<\/strong><br><strong>No.<\/strong> Capsules should be <strong>swallowed whole<\/strong>. Do not crush or chew the enteric-coated pellets.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>How long should I take OMEZ for reflux or ulcers?<\/strong><br>For most ulcers and reflux, adults take <strong>20 mg once daily for 4\u20138 weeks<\/strong> (duodenal ulcers may be <strong>2\u20134 weeks<\/strong>). Your doctor will advise the exact duration.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>What if my reflux symptoms aren\u2019t better after 2 weeks on 20 mg?<\/strong><br>If <strong>20 mg daily<\/strong> for <strong>2 weeks<\/strong> does not control symptoms, <strong>further investigation<\/strong> is recommended.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Is OMEZ used with antibiotics for <em>H. pylori<\/em>?<\/strong><br>Yes. For <strong>H. pylori-positive duodenal ulcers<\/strong>, OMEZ is used <strong>as part of an eradication programme with appropriate antibiotics<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>I take NSAIDs for pain. Can OMEZ help protect my stomach?<\/strong><br>Yes. OMEZ <strong>treats<\/strong> NSAID-associated gastric\/duodenal lesions (<strong>20 mg daily<\/strong>) and can be used for <strong>prevention<\/strong> while you are on NSAIDs (<strong>20 mg daily<\/strong>).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Can OMEZ affect other medicines?<\/strong><br>Yes. Important interactions include <strong>clopidogrel<\/strong> (activation reduced), <strong>warfarin<\/strong>\/<strong>phenytoin<\/strong> (may need monitoring and dose changes), <strong>digoxin<\/strong> (exposure slightly increased), <strong>nelfinavir<\/strong> (contraindicated), <strong>atazanavir<\/strong> (not recommended), <strong>tacrolimus<\/strong> and <strong>methotrexate<\/strong> (levels may rise), and some medicines that need stomach acid for absorption (e.g., <strong>ketoconazole, itraconazole, posaconazole, erlotinib<\/strong>). Always check with your pharmacist or doctor.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Can OMEZ cause low magnesium or bone problems?<\/strong><br>Long-term\/high-dose PPI use has been linked to <strong>low magnesium<\/strong> and a <strong>small increase in fracture risk<\/strong>. Your clinician may monitor magnesium, especially if you also take <strong>digoxin<\/strong> or <strong>diuretics<\/strong>, and will aim for the <strong>lowest effective dose<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>What should I do if I develop persistent diarrhoea?<\/strong><br>Contact your doctor. OMEZ use has been associated (frequency not known) with <strong>Clostridium difficile-associated diarrhoea<\/strong>, particularly in hospitalised patients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Does OMEZ affect tumour marker tests like Chromogranin A?<\/strong><br>Yes. OMEZ can <strong>increase CgA<\/strong> and <strong>interfere<\/strong> with tests for neuroendocrine tumours. <strong>Stop for at least 5 days<\/strong> before testing; if still raised, repeat <strong>14 days<\/strong> after stopping.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>OMEZ is a prescription medicine that reduces the amount of acid made in your stomach. It contains omeprazole, a proton pump inhibitor (PPI). Lowering stomach acid helps ulcers to heal, eases heartburn caused by gastro-oesophageal reflux disease (GORD), and treats conditions where the stomach produces too much acid. What it is and what it is &#8230; <a title=\"OMEZ :Uses, Dose, Side-Effects, Precautions\" class=\"read-more\" href=\"https:\/\/rxquora.com\/en\/omez-uses-dose-side-effects-precautions\/\" aria-label=\"Read more about OMEZ :Uses, Dose, Side-Effects, Precautions\">Read more<\/a><\/p>\n","protected":false},"author":5,"featured_media":2182,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[34],"tags":[],"class_list":["post-2144","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gastritis"],"_links":{"self":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/posts\/2144","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/comments?post=2144"}],"version-history":[{"count":0,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/posts\/2144\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/media\/2182"}],"wp:attachment":[{"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/media?parent=2144"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/categories?post=2144"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rxquora.com\/en\/wp-json\/wp\/v2\/tags?post=2144"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}