Stilpane Tablet is a widely prescribed medication in South Africa for managing mild to moderate pain and fever. It is a combination drug that provides multi-faceted pain relief while addressing other symptoms such as muscle tension and fatigue. In this detailed guide, we will explore the composition, uses, side effects, precautions, and more .
Active Ingredients and Composition
The efficacy of Stilpane Tablet is attributed to its combination of active ingredients, each with a specific role in alleviating pain and other symptoms. Each tablet contains:
- Paracetamol (Acetaminophen) 320 mg:
Paracetamol is one of the most widely used over-the-counter medications for pain and fever. It works by inhibiting the production of prostaglandins, chemicals in the body that cause inflammation and pain. - Caffeine 32 mg:
Caffeine enhances the effects of paracetamol, making the combination more effective in relieving pain. It also counteracts drowsiness, a potential side effect of other ingredients in the tablet. - Codeine Phosphate 8 mg:
Codeine is a mild opioid that acts on the central nervous system to relieve pain. It is particularly useful for moderate pain that does not respond well to non-opioid medications. - Meprobamate 150 mg:
Meprobamate is a muscle relaxant and mild sedative. It helps reduce muscle tension and promotes relaxation, making Stilpane effective for pain associated with muscle spasms or stress.
Therapeutic Uses
Stilpane Tablet is versatile in its applications and is used for a range of conditions.
1. Pain Relief
Stilpane is especially effective for managing:
- Headaches: Including tension headaches and migraines, where its combination of paracetamol, codeine, and caffeine proves highly effective.
- Dental Pain: Such as toothaches and post-dental surgery discomfort.
- Musculoskeletal Pain: Including back pain, neck pain, and muscle spasms.
- Post-Surgical Pain: For managing moderate pain after surgical procedures.
- Menstrual Cramps: Where muscle relaxation from meprobamate provides added relief.
- Arthritis and Joint Pain: It alleviates the discomfort associated with inflammation and stiffness.
2. Fever Reduction

Paracetamol in Stilpane helps lower fever, making it useful for conditions such as colds, flu, and other febrile illnesses.
Dosage and Administration
Recommended Dosage
- Adults and Adolescents (12+ years):
Take 1-2 tablets every 4-6 hours as needed for pain relief. Do not exceed 8 tablets in 24 hours. - Children Under 12 Years:
Stilpane is not recommended for children under 12 due to the presence of codeine and meprobamate, which may cause serious side effects in younger individuals.
How to Take Stilpane
- Swallow the tablet whole with a glass of water.
- It can be taken with or without food, though taking it with food may help reduce nausea.
Missed Dose:
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose to make up for a missed one.
Do not use STILPANE Tablets for longer than 5 days.
Potential Side Effects
While Stilpane is generally safe when used as directed, it can cause side effects in some individuals.
Common Side Effects:
- Drowsiness and Dizziness: Caused by codeine and meprobamate, which act on the central nervous system.
- Nausea and Vomiting: Particularly in individuals sensitive to codeine or caffeine.
- Constipation: A common issue with opioid medications like codeine.
- Nervousness or Restlessness: Due to the caffeine content.
Serious Side Effects:
- Respiratory Depression: Difficulty breathing caused by codeine, especially in higher doses or in individuals with respiratory conditions.
- Liver Damage: Paracetamol overdose can cause severe liver toxicity, particularly in individuals with pre-existing liver disease or those who consume alcohol regularly.
- Allergic Reactions: Symptoms include rash, itching, swelling, or difficulty breathing. Seek immediate medical attention if these occur.
- Dependence and Withdrawal Symptoms: Prolonged use of codeine and meprobamate may lead to physical dependence and withdrawal symptoms upon discontinuation.
When to Seek Medical Attention:
If you experience serious side effects such as difficulty breathing, confusion, or signs of an allergic reaction, seek emergency medical care immediately.
Precautions and Contraindications
Who Should Avoid Stilpane?
- Allergy: If you are allergic to paracetamol, caffeine, codeine, or meprobamate.
- Respiratory Disorders: Such as severe asthma or respiratory depression.
- Pregnancy and Breastfeeding: Use only under the advice of a healthcare provider, as codeine can affect the fetus or infant.
- Children Under 12 Years: Codeine and meprobamate pose risks of serious side effects in younger children.
Special Precautions:
- Liver or Kidney Disease: Individuals with impaired liver or kidney function should use Stilpane with caution and under medical supervision.
- Substance Abuse History: Codeine is an opioid with the potential for abuse and addiction.
- Elderly Patients: Increased risk of side effects such as drowsiness and dizziness.
Drug Interactions:
- Alcohol: Avoid consuming alcohol while taking Stilpane, as it increases the risk of liver damage and enhances the sedative effects of the medication.
- Other CNS Depressants: Including sedatives, tranquilizers, or certain antihistamines, which can amplify drowsiness and respiratory depression.
- Other Medications Containing Paracetamol or Codeine: Avoid doubling up on medications with similar ingredients to prevent overdose.
Warnings and Overdose Risks
1. Risk of Overdose:
An overdose of Stilpane can be life-threatening, especially due to the paracetamol (320 mg) and codeine (8 mg) content. Symptoms of overdose include:
- Extreme drowsiness or confusion.
- Difficulty breathing.
- Nausea and vomiting.
- Liver damage, which may present as jaundice or abdominal pain.
Seek immediate medical attention if an overdose is suspected.
2. Risk of Addiction:
Codeine is an opioid that can lead to physical dependence if used for extended periods. Meprobamate, though not an opioid, also has a sedative effect and may cause dependency in some individuals. Use Stilpane only as prescribed, and avoid long-term use without consulting your healthcare provider.
3. Driving and Machinery Use:
Stilpane may impair your ability to drive or operate heavy machinery due to its sedative effects. Avoid these activities if you feel drowsy or dizzy after taking the medication.
Storage and Handling
- Storage Conditions: Store Stilpane in a cool, dry place, away from direct sunlight and moisture.
- Keep Out of Reach of Children: Accidental ingestion by children can cause serious harm.
Conclusion
Stilpane Tablet is a powerful and effective medication for managing moderate to severe pain and fever. Its combination of paracetamol, caffeine, codeine, and meprobamate provides a multi-faceted approach to pain relief. However, it is essential to use Stilpane responsibly, adhering to prescribed dosages and taking note of precautions to avoid side effects, addiction, or overdose risks.
Always consult a healthcare professional if you have concerns or if your symptoms persist despite treatment. By using Stilpane as directed, you can safely and effectively manage pain and improve your quality of life.
Frequently Asked Questions (FAQs)
Yes, Stilpane is effective for managing migraines due to its combination of paracetamol, caffeine, and codeine. However, consult your doctor for long-term migraine management.
Stilpane should only be used during pregnancy if prescribed by a healthcare provider. Codeine can affect the baby, especially in the later stages of pregnancy.
Avoid taking Stilpane with other medications containing paracetamol, codeine, or caffeine to prevent overdose. Always consult your doctor before combining medications.
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